miRBase entry: hsa-mir-200c

Stem-loop hsa-mir-200c


Accession
MI0000650
Symbol
HGNC: MIR200C
Description
Homo sapiens hsa-mir-200c precursor miRNA
Gene family
MIPF0000019; mir-8

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

A study confirmed that the 3′UTR of glutathione S-transferase mu 3 is a direct target of hsa-mir-200c by co-transfecting a scrambled control siRNA with different GSTM3 3′UTR plasmids [PMC9688189].

Literature search
729 open access papers mention hsa-mir-200c
(4951 sentences)

Sequence

285921 reads, 2318 reads per million, 157 experiments
cccuCGUCUUACCCAGCAGUGUUUGGgugcgguugggagucucUAAUACUGCCGGGUAAUGAUGGAgg
.(((((((((((((.((((((((.(((.((........))))).)))))))).)))))).))).))))

Structure
c    -   -      A        U   u  ggu 
 ccuC GUC UUACCC GCAGUGUU GGg gc   u
 |||| ||| |||||| |||||||| ||| ||    
 ggAG UAG AAUGGG CGUCAUAA cuc ug   g
-    G   U      C        U   -  agg 


Annotation confidence High
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context
chr12: 6963699-6963766 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-200c
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-200c is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-200c is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-200c is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-200c-5p

Accession MIMAT0004657
Description Homo sapiens hsa-miR-200c-5p mature miRNA
Sequence 5 - CGUCUUACCCAGCAGUGUUUGG - 26
Evidence experimental
cloned [3]
Database links
Predicted targets

Mature hsa-miR-200c-3p

Accession MIMAT0000617
Description Homo sapiens hsa-miR-200c-3p mature miRNA
Sequence 44 - UAAUACUGCCGGGUAAUGAUGGA - 66
Evidence experimental
cloned [1-4], Northern [2]
Database links
Predicted targets

References

  1. PubMed ID: 15183728
    Human embryonic stem cells express a unique set of microRNAs
    "Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS"
    "Dev Biol (2004) 270:488-498

  2. PubMed ID: 14573789
    Reduced accumulation of specific microRNAs in colorectal neoplasia
    "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
    "Mol Cancer Res (2003) 1:882-891

  3. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  4. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043