miRBase entry: hsa-mir-374a

Stem-loop hsa-mir-374a


Accession
MI0000782
Symbol
HGNC: MIR374A
Description
Homo sapiens hsa-mir-374a precursor miRNA
Gene family
MIPF0000288; mir-374

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR374A is a microRNA that has been identified as a direct regulator of the p140Cap protein in lung, gastric, and cutaneous squamous carcinoma cells, linking miRNAs to epithelial cancer cell features through the inhibition of p140Cap expression [PMC5357316]. It is part of a panel of nine miRNAs, including miR-21, miR-218, miR-193b, miR-331, MIR374A, miR548c, miR520f, miR27b and miR-30b that have been associated with tumor volume and shown to have a 67% sensitivity and 80% specificity [PMC9965735]. MIR374A has also been detected in cerebrospinal fluid (CSF) samples from glioblastoma patients and found to correlate with levels detected from tissue biopsies [PMC7014190]. It has been associated with malignancy and identified as an independent predictor for LOFS (loss of fetal signal) when combined with MIR320b [PMC6196565]. In addition to its role in cancer cells, MIR374A has also been implicated in distinguishing hypoxic-ischemic encephalopathy (HIE) patients from healthy newborns and assessing the severity of HIE [PMC7296108]. Furthermore, MIR374A is involved in autophagy regulation by targeting RAB5A and UVRAG genes [PMC4389881]. Overall, MIR374A plays a role in various biological processes including cancer development and progression as well as HIE severity assessment.

Literature search
67 open access papers mention hsa-mir-374a
(407 sentences)

Sequence

165954 reads, 1036 reads per million, 146 experiments
uacaucggccaUUAUAAUACAACCUGAUAAGUGuuauagcaCUUAUCAGAUUGUAUUGUAAUUgucugugua
(((((.(((.((((((((((((.(((((((((((....))))))))))).)))))))))))).))).)))))

Structure
     c   c            C           u 
uacau ggc aUUAUAAUACAA CUGAUAAGUGu a
||||| ||| |||||||||||| |||||||||||  
augug cug UAAUGUUAUGUU GACUAUUCacg u
     u   U            A           a 


Annotation confidence High
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Genome context
chrX: 74287286-74287357 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-374a
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-374a is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-374a-5p

Accession MIMAT0000727
Description Homo sapiens hsa-miR-374a-5p mature miRNA
Sequence 12 - UUAUAAUACAACCUGAUAAGUG - 33
Evidence experimental
cloned [1-4], Northern [1]
Database links
Predicted targets

Mature hsa-miR-374a-3p

Accession MIMAT0004688
Description Homo sapiens hsa-miR-374a-3p mature miRNA
Sequence 42 - CUUAUCAGAUUGUAUUGUAAUU - 63
Evidence experimental
cloned [3]
Database links
Predicted targets

References

  1. PubMed ID: 15183728
    Human embryonic stem cells express a unique set of microRNAs
    "Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS"
    "Dev Biol (2004) 270:488-498

  2. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  3. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  4. PubMed ID: 16274478
    Identification of clustered microRNAs using an ab initio prediction method
    Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
    BMC Bioinformatics (2005) 6:267