miRBase entry: bta-mir-129-2

Stem-loop bta-mir-129-2


Accession
MI0009729
Description
Bos taurus bta-mir-129-2 precursor miRNA
Gene family
MIPF0000073; mir-129

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

Bta-mir-129 is a bovine miRNA that has been studied in various contexts. In one study, it was among the miRNAs assessed in both murine and bovine samples [PMC9188571]. Another study found that bta-mir-129 was one of the miRNAs involved in the regulation of IGF-1 expression, along with other circRNAs and miRNAs [PMC9821774]. Specifically, bta-mir-129 and a circRNA called novel_circ_016821 were identified as the main regulatory factors [PMC9821774]. In a different study, bta-mir-129 was found to be increased at day 7 of the estrous cycle compared to day 3 [PMC4156418]. Additionally, it was up-regulated in pregnant cows but not detected across the estrous cycle [PMC7969882]. Finally, at parturition, bta-mir-129 was part of a group of miRNAs that showed time-dependent expression patterns, with some being overexpressed and others being downregulated [PMC9445238]. These findings highlight the involvement of bta-mir-129 in various biological processes and its potential as a biomarker or therapeutic target.

Literature search
6 open access papers mention bta-mir-129-2
(14 sentences)

Sequence

1429 reads, 70 reads per million, 64 experiments
cugcccuucgcgaauCUUUUUGCGGUCUGGGCUUGCUguacauaacucaauagccggAAGCCCUUACCCCAAAAAGCAUucgcggagggcgcac
.(((((((((((((((((((((.(((..(((((((((((..........)))))...))))))..))).))))))).))))))))))))))...

Structure
--c              -       C   CU      ---     acau 
   ugcccuucgcgaau CUUUUUG GGU  GGGCUU   GCUgu    a
   |||||||||||||| ||||||| |||  ||||||   |||||     
   gcgggaggcgcuUA GAAAAAC CCA  CCCGAA   cgaua    a
cac              C       C   UU      ggc     acuc 


Annotation confidence High
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Genome context
chr15: 74898231-74898324 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from bta-mir-129-2
Name Accession Chromosome Start End Strand Confidence




Database links

Mature bta-miR-129-5p

Accession MIMAT0009221
Description Bos taurus bta-miR-129-5p mature miRNA
Sequence 16 - CUUUUUGCGGUCUGGGCUUGCU - 37
Evidence experimental
cloned [3]

Mature bta-miR-129-3p

Accession MIMAT0009222
Description Bos taurus bta-miR-129-3p mature miRNA
Sequence 58 - AAGCCCUUACCCCAAAAAGCAU - 79
Evidence experimental
cloned [3]

References

  1. PubMed ID: 18215311
    miRNAminer: a tool for homologous microRNA gene search
    "Artzi S, Kiezun A, Shomron N"
    "BMC Bioinformatics (2008) 9:39

  2. PubMed ID: 19758457
    Characterization of bovine miRNAs by sequencing and bioinformatics analysis
    Jin W, Grant JR, Stothard P, Moore SS, Guan LL
    BMC Mol Biol (2009) 10:90

  3. PubMed ID: 18945293
    Annotation of 390 bovine miRNA genes by sequence similarity with other species
    "Strozzi F, Mazza R, Malinverni R, Williams JL"
    "Anim Genet (2009) 40:125