miRBase entry: bta-mir-92a-1

Stem-loop bta-mir-92a-1


Accession
MI0009905
Description
Bos taurus bta-mir-92a-1 precursor miRNA
Gene family
MIPF0000013; mir-25

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

Bta-mir-92a is a microRNA that has been identified as a potential diagnostic tool for animals exposed to pathogens [PMC4990326]. In a study comparing positive and negative groups, it was found that the negative group had a higher number of counts for bta-mir-92a [PMC4990326]. High expression levels of bta-mir-92a have also been detected in skeletal muscle [PMC4410957]. Bta-mir-92a is one of the top 10 highly expressed miRNAs in various samples, indicating its abundance and potential importance [PMC4156418]. Furthermore, bta-mir-92a is one of the immune-related miRNAs that are highly expressed in cattle [PMC6940744]. In different studies, bta-mir-92a has been found to be misregulated in liver and tongue tissues [PMC6691986]. It has also been shown to be downregulated in extracellular vesicles secreted by arrested embryos but upregulated in competent embryos [PMC7727673]. Bta-mir-92a is co-detected with other miRNAs in 8-cell and blastocyst samples, suggesting its involvement in early embryonic development [PMC8060439]. Additionally, it is one of the immune-related miRNAs highly expressed in bovine samples [PMC7070426]. Bta-mir-92a has also been reported as highly expressed in blood exosomes of dairy cows [PMC9445238]. Overall, bta-mir-92a shows potential as a diagnostic tool and plays a role in various biological processes.

Literature search
30 open access papers mention bta-mir-92a-1
(67 sentences)

Sequence

519910 reads, 5255 reads per million, 77 experiments
cuuucuacacagguugggaucgguugcaaugcuguguuucuguauggUAUUGCACUUGUCCCGGCCUGUugaguuugg
....((..((((((((((((.(((.(((((((((((......)))))))))))))).))))))))))))..)).....

Structure
-cuuu  ac            c   u           uu 
     cu  acagguugggau ggu gcaaugcugug  u
     ||  |||||||||||| ||| |||||||||||   
     ga  UGUCCGGCCCUG UCA CGUUAUgguau  c
gguuu  gu            U   -           gu 


Annotation confidence Not enough data
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Genome context
chr12: 66421937-66422014 [+]
Clustered miRNAs
5 other miRNAs are < 10 kb from bta-mir-92a-1
Name Accession Chromosome Start End Strand Confidence




Database links

Mature bta-miR-92a

Accession MIMAT0009383
Description Bos taurus bta-miR-92a mature miRNA
Sequence 48 - UAUUGCACUUGUCCCGGCCUGU - 69
Evidence experimental
cloned [2]

References

  1. PubMed ID: 19758457
    Characterization of bovine miRNAs by sequencing and bioinformatics analysis
    Jin W, Grant JR, Stothard P, Moore SS, Guan LL
    BMC Mol Biol (2009) 10:90

  2. PubMed ID: 18945293
    Annotation of 390 bovine miRNA genes by sequence similarity with other species
    "Strozzi F, Mazza R, Malinverni R, Williams JL"
    "Anim Genet (2009) 40:125