Accession
MI0000065
Symbol
HGNC:
MIRLET7D
Description
Homo sapiens
hsa-let-7d precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIRLET7D is a multicomponent RNA-protein complex that plays a crucial role in nucleolar organization [PMC9455804]. It specifically interacts with non-coding RNAs (ncRNAs) and not messenger RNAs (mRNAs) [PMC6527704]. In human primary lung fibroblasts, the loss of MIRLET7D, as well as the downregulation of EXOSC10 and EZH2, leads to increased cell migration [PMC6527704'>PMC6527704]. This decrease in MIRLET7D levels is associated with elevated expression of MIRLET7D targets and fibrosis markers [PMC6527704]. Biotinylated MIRCTRL and MIRLET7D were transfected to study their effects at a concentration of 20 nM [PMC6527704]. Mutations in MIRLET7D have been observed, including hotspot indels mutations in the upstream flanking sequence [PMC9708458]. In an experimental system, alterations in MIRLET7D and Cited2 were found to be involved in chromatin remodeling [PMC9059753]. The promoters of MIRLET7D targets were analyzed using chromatin immunoprecipitation (ChIP) with antibodies specific for acetylated H3K27 or trimethylated H3K27, revealing the sequential order of events after transfection with MIRCTRL or MIRLET7D alone or in combination with shRNAs specific for HDAC1 [PMC6527704]. References: - PMC9455804 - PMC6527704 - PMC9708458 - PMC9059753
Literature search
1090 open access papers mention hsa-let-7d
(6011 sentences)
(6011 sentences)
Sequence
1103859
reads,
4366
reads per million, 145 experiments
ccuaggaAGAGGUAGUAGGUUGCAUAGUUuuagggcagggauuuugcccacaaggagguaaCUAUACGACCUGCUGCCUUUCUuagg
(((((((.((((((((((((((.((((((...((((((.....))))))..........)))))).)))))))))))))))))))))
(((((((.((((((((((((((.((((((...((((((.....))))))..........)))))).)))))))))))))))))))))
Structure
A C -------uua g
ccuagga GAGGUAGUAGGUUG AUAGUU gggcag g
||||||| |||||||||||||| |||||| |||||| a
ggauUCU UUCCGUCGUCCAGC UAUCaa cccguu u
- A uggaggaaca u
Annotation confidence
High
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].
Genome context
chr9: 94178834-94178920 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-let-7d
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-let-7d is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-let-7d-5p
| Accession | MIMAT0000065 |
| Description | Homo sapiens hsa-let-7d-5p mature miRNA |
| Sequence | 8 - AGAGGUAGUAGGUUGCAUAGUU - 29 |
| Evidence |
experimental
cloned [1-4], Northern [1], Illumina [5] |
| Database links |
|
| Predicted targets |
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Mature hsa-let-7d-3p
| Accession | MIMAT0004484 |
| Description | Homo sapiens hsa-let-7d-3p mature miRNA |
| Sequence | 62 - CUAUACGACCUGCUGCCUUUCU - 83 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
References
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