Accession
MI0000065
Symbol
HGNC:
MIRLET7D
Description
Homo sapiens
hsa-let-7d precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIRLET7D is a microRNA that plays a crucial role in the formation of the MiCEE complex, which is essential for proper nucleolar organization by tethering regulated genes to the perinucleolar region [PMC9455804]. This microRNA selectively associates with non-coding RNAs rather than mRNAs, as demonstrated by pull-down assays [PMC6527704]. Loss of function (LOF) studies using antagomiR probes for MIRLET7D, as well as knockdown of associated proteins EXOSC10 and EZH2, have shown that reduced MIRLET7D activity leads to increased cell migration in control human primary lung fibroblasts [PMC6527704]. Furthermore, decreased levels of MIRLET7D correlate with upregulation of its target genes and fibrosis markers, suggesting its involvement in fibrotic processes [PMC6527704]. Mutations and indels in the flanking sequence of MIRLET7D have been identified in various cancers, indicating its potential role in tumorigenesis [PMC9708458]. Additionally, alterations in MIRLET7D expression may be implicated in chromatin remodeling processes as observed in certain rat models [PMC9059753]. Chromatin immunoprecipitation (ChIP) analyses further confirm that MIRLET7D affects the chromatin state at target promoters by influencing histone modification patterns [PMC6527704].
Literature search
1090 open access papers mention hsa-let-7d
(6011 sentences)
(6011 sentences)
Sequence
1103859
reads,
4366
reads per million, 145 experiments
ccuaggaAGAGGUAGUAGGUUGCAUAGUUuuagggcagggauuuugcccacaaggagguaaCUAUACGACCUGCUGCCUUUCUuagg
(((((((.((((((((((((((.((((((...((((((.....))))))..........)))))).)))))))))))))))))))))
(((((((.((((((((((((((.((((((...((((((.....))))))..........)))))).)))))))))))))))))))))
Structure
A C -------uua g
ccuagga GAGGUAGUAGGUUG AUAGUU gggcag g
||||||| |||||||||||||| |||||| |||||| a
ggauUCU UUCCGUCGUCCAGC UAUCaa cccguu u
- A uggaggaaca u
Annotation confidence
High
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].
Genome context
chr9: 94178834-94178920 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-let-7d
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-let-7d is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-let-7d-5p
| Accession | MIMAT0000065 |
| Description | Homo sapiens hsa-let-7d-5p mature miRNA |
| Sequence | 8 - AGAGGUAGUAGGUUGCAUAGUU - 29 |
| Evidence |
experimental
cloned [1-4], Northern [1], Illumina [5] |
| Database links |
|
| Predicted targets |
|
Mature hsa-let-7d-3p
| Accession | MIMAT0004484 |
| Description | Homo sapiens hsa-let-7d-3p mature miRNA |
| Sequence | 62 - CUAUACGACCUGCUGCCUUUCU - 83 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
References
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