miRBase entry: hsa-let-7e

Stem-loop hsa-let-7e

Homo sapiens hsa-let-7e precursor miRNA
Gene family
MIPF0000002; let-7

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIRLET7E is a microRNA gene that has been identified in various studies. It is a member of the let-7 family of microRNAs and has been found to be differentially expressed in different contexts. In a study on pediatric cancers, a custom gene panel was designed to include MIRLET7E for mutation profiling [PMC7341754]. Another study identified MIRLET7E as one of the differentially expressed microRNAs [PMC4052096]. It has been shown that the promoter region of MIRLET7E can be hypermethylated, leading to decreased expression [PMC4053776]. In breast cancer cell lines, MIRLET7E was found to be epigenetically repressed by lysine-specific demethylase 5B (JARID1B) [PMC4053776]. The expression profiles of MIRLET7E were missing in an independent dataset, and its expression levels were validated along with other genes [PMC10113532]. In the context of liver disorders, it was found that MIRLET7E was down-regulated by CPV treatment, which may contribute to its therapeutic effect [PMC6957807]. Furthermore, MIRLET7E has been associated with negative regulation of the anti-inflammatory cytokine IL-10 and has been implicated in autoimmune disorders and liver fibrosis [PMC6957807]. The interaction between NEAT1 and various genes including MIRLET7E was also observed in a study [PMC9730017]. Finally, in bovine neutrophils under supplementation with quercetin during inflammation induction, an inverse relationship between MIRLET7E expression and IL6 mRNA levels was observed [PMC5422244].

Literature search
1095 open access papers mention hsa-let-7e
(6132 sentences)


1076185 reads, 5118 reads per million, 133 experiments

  c   cU   G                U  -------  a g 
cc ggg  GAG UAGGAGGUUGUAUAGU ga       gg g a
|| |||  ||| |||||||||||||||| ||       || |  
gg ccC  UUC AUCCUCCGGCAUAUCa cu       cc c c
  a   CU   G                -  agaggaa  - a 

Annotation confidence High
Do you think this miRNA is real?
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context
chr19: 51692786-51692864 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-let-7e
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-let-7e is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-let-7e-5p

Accession MIMAT0000066
Description Homo sapiens hsa-let-7e-5p mature miRNA
Evidence experimental
cloned [1-4], Northern [1], Illumina [5]
Database links
Predicted targets

Mature hsa-let-7e-3p

Accession MIMAT0004485
Description Homo sapiens hsa-let-7e-3p mature miRNA
Evidence experimental
cloned [3]
Database links
Predicted targets


  1. PubMed ID: 11679670
    Identification of novel genes coding for small expressed RNAs
    "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
    "Science (2001) 294:853-858

  2. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  3. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  4. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  5. PubMed ID: 20158877
    Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha
    Koh W, Sheng CT, Tan B, Lee QY, Kuznetsov V, Kiang LS, Tanavde V
    BMC Genomics (2010) 11:S6