Accession
MI0000067
Symbol
HGNC:
MIRLET7F1
Description
Homo sapiens
hsa-let-7f-1 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIRLET7F1 is a microRNA gene that is included in a custom gene panel designed for mutation profiling of pediatric cancers [PMC7341754]. The panel includes coding exons of 366 cancer-associated genes, untranslated regions and introns of 16 genes for detecting structural variations, and specific regions for detecting TERT rearrangement and promoter/enhancer mutation [PMC7341754]. In addition, the panel includes the promoter and enhancer regions of FGFR3 and MYC, as well as 11 microRNA genes including MIRLET7F1 [PMC7341754]. In a study, MIRLET7F1 was identified as one of the candidate target genes in pediatric cancers [PMC5791735]. MIRLET7F1 interacts with HNRNPM along with other miRNAs, protein coding genes, rRNAs, lncRNAs, and pseudogenes [PMC9730017]. The SNP rs10512230 is flanked by the PTPDC1 gene along with MIRLET7A1 (Let-7a-1), MIRLET7F1 (Let-7f-1), and MIRLET7D (Let-7d) genes [PMC6202974]. These microRNA genes including MIRLET7A1, MIRLET7F1, and MIRLET7D are involved in cancer and DNA damage response pathways [PMC6202974]. The custom gene panel used targeted capture technology to analyze various genomic regions including microRNA genes like MIRLET7F1 for copy number analysis in pediatric cancers [PMC7815088].
Literature search
1093 open access papers mention hsa-let-7f-1
(6143 sentences)
(6143 sentences)
Sequence
24889328
reads,
65280
reads per million, 158 experiments
ucagagUGAGGUAGUAGAUUGUAUAGUUgugggguagugauuuuacccuguucaggagauaaCUAUACAAUCUAUUGCCUUCCCuga
((((.(.((((((((((((((((((((((((((((((.....))))))).........))))))))))))))))))))))).)))))
((((.(.((((((((((((((((((((((((((((((.....))))))).........))))))))))))))))))))))).)))))
Structure
a U --------- u
ucag g GAGGUAGUAGAUUGUAUAGUUgu gggguag g
|||| | ||||||||||||||||||||||| ||||||| a
aguC C UUCCGUUAUCUAACAUAUCaaua ucccauu u
- C gaggacuug u
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr9: 94176347-94176433 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-let-7f-1
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-let-7f-1 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-let-7f-5p
| Accession | MIMAT0000067 |
| Description | Homo sapiens hsa-let-7f-5p mature miRNA |
| Sequence | 7 - UGAGGUAGUAGAUUGUAUAGUU - 28 |
| Evidence |
experimental
cloned [1,3-5], Northern [1], Illumina [6] |
| Database links |
|
| Predicted targets |
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Mature hsa-let-7f-1-3p
| Accession | MIMAT0004486 |
| Description | Homo sapiens hsa-let-7f-1-3p mature miRNA |
| Sequence | 63 - CUAUACAAUCUAUUGCCUUCCC - 84 |
| Evidence |
experimental
cloned [4] |
| Database links |
|
| Predicted targets |
|
References
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