Accession
MI0000070
Symbol
HGNC:
MIR16-1
Description
Homo sapiens
hsa-mir-16-1 precursor miRNA mir-15
Gene
family?
family?
RF00455;
mir-15
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR16-1 is a microRNA that is deleted in del13q, resulting in the loss of its regulatory function in BCL2 expression, which is crucial for cell cycle regulation and apoptosis [PMC7280959]. In a study on the response to hydroxyurea treatment, it was found that the expression of MIR16-1 showed a significant direct correlation with HbF levels (r = 0.809) [PMC9825386]. This suggests that MIR16-1 may play a role in the regulation of HbF production. References: - [PMC7280959]: Stilgenbauer, S., & Zenz, T. (2016). Understanding and managing ultra high-risk chronic lymphocytic leukemia. Hematology/oncology clinics of North America, 30(6), 1193–1213. https://doi.org/10.1016/j.hoc.2016.07.003 - [PMC9825386]: Sankaran, V.G., & Orkin S.H. (2021). The switch from fetal to adult hemoglobin production: In search of targets for pharmacologic intervention in sickle cell disease and β-thalassemia. Blood Cells Mol Dis., 87:102525 https://doi.org/10.1016/j.bcmd.2020.102525
Literature search
730 open access papers mention hsa-mir-16-1
(3475 sentences)
(3475 sentences)
Sequence
2315134
reads,
10398
reads per million, 158 experiments
gucagcagugccuUAGCAGCACGUAAAUAUUGGCGuuaagauucuaaaauuaucuCCAGUAUUAACUGUGCUGCUGAaguaagguugac
((((((..(((.((((((((((((.((((((((.(.(((..........))).).)))))))).)).)))))))))).)))..))))))
((((((..(((.((((((((((((.((((((((.(.(((..........))).).)))))))).)).)))))))))).)))..))))))
Structure
ag c - A C u gauu
gucagc ugc uUAGCAGCAC GU AAUAUUGG G uaa c
|||||| ||| |||||||||| || |||||||| | |||
caguug aug AGUCGUCGUG CA UUAUGACC c auu u
ga a U A u u aaaa
Annotation confidence
High
Do you think this miRNA is real?
Comments
Human miR-16 has been cloned by independent groups [1,2]. This precursor sequence maps to chromosome 13, and was named mir-16 in [1] and mir-16-precursor-13 in [2]. Lim et al. reported 2 identical chromosome 13 loci, which appear to map to the same locus in subsequent genome assemblies. This gene and miR-15a are clustered within 0.5 kb at 13q14. This region has been shown to be deleted in more than half of B cell chronic lymphocytic leukemias (CLL). Both miR-15a and miR-16 are deleted or down-regulated in more than two thirds of CLL cases [3]. A second putative mir-16 hairpin precursor is located on chromosome 3 (MIR:MI0000738).
Genome context
chr13: 50048973-50049061 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-16-1
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-16-1 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-16-5p
| Accession | MIMAT0000069 |
| Description | Homo sapiens hsa-miR-16-5p mature miRNA |
| Sequence | 14 - UAGCAGCACGUAAAUAUUGGCG - 35 |
| Evidence |
experimental
cloned [1,3-4,6-8], Northern [3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-16-1-3p
| Accession | MIMAT0004489 |
| Description | Homo sapiens hsa-miR-16-1-3p mature miRNA |
| Sequence | 56 - CCAGUAUUAACUGUGCUGCUGA - 77 |
| Evidence |
experimental
cloned [8] |
| Database links |
|
| Predicted targets |
|
References
|
