Accession
MI0000073
Symbol
HGNC:
MIR19A
Description
Homo sapiens
hsa-mir-19a precursor miRNA mir-19
Gene
family?
family?
RF00245;
mir-19
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR19A is a microRNA that is upregulated in certain conditions. It is activated by the TF MYC through two signaling pathways, resulting in the upregulation of downstream regulators NFE2L1, FOXC1, and MIR19A [PMC8002730]. In the context of placenta samples from mothers with macrosomic babies, miR17, miR18a, MIR19A, miR19b, miR20a, and miR92a were found to be upregulated [PMC5572592]. MIR19A is a type of microRNA that plays a role in gene regulation. It has been found to be upregulated in certain conditions. In particular, the TF MYC activated by two signaling pathways has been shown to upregulate downstream regulators NFE2L1, FOXC1, and MIR19A [PMC8002730]. Additionally, placenta samples from mothers with macrosomic babies have shown an upregulation of several microRNAs including MIR19A [PMC5572592].
Literature search
313 open access papers mention hsa-mir-19a
(1597 sentences)
(1597 sentences)
Sequence
545193
reads,
9302
reads per million, 118 experiments
gcaguccucuguuAGUUUUGCAUAGUUGCACUACAagaagaauguaguUGUGCAAAUCUAUGCAAAACUGAugguggccugc
((((.((.(((((((((((((((((((((((((((.......))))...))))))..))))))))))))))))).)).))))
((((.((.(((((((((((((((((((((((((((.......))))...))))))..))))))))))))))))).)).))))
Structure
u u -- --- ag
gcag cc cuguuAGUUUUGCAUAG UUGCAC UACA a
|||| || ||||||||||||||||| |||||| |||| a
cguc gg gguAGUCAAAACGUAUC AACGUG augu g
c u UA Uug aa
Annotation confidence
High
Do you think this miRNA is real?
Comments
This sequence maps to chromosome 13 and is named miR-19a precursor-13 in reference [2].
Genome context
chr13: 91350891-91350972 [+]
Clustered miRNAs
5 other miRNAs are < 10 kb from hsa-mir-19a
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-19a is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-19a is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-19a is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-19a-5p
| Accession | MIMAT0004490 |
| Description | Homo sapiens hsa-miR-19a-5p mature miRNA |
| Sequence | 14 - AGUUUUGCAUAGUUGCACUACA - 35 |
| Evidence |
experimental
cloned [4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-19a-3p
| Accession | MIMAT0000073 |
| Description | Homo sapiens hsa-miR-19a-3p mature miRNA |
| Sequence | 49 - UGUGCAAAUCUAUGCAAAACUGA - 71 |
| Evidence |
experimental
cloned [1-5], Northern [1] |
| Database links |
|
| Predicted targets |
|
References
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