Accession
MI0000074
Symbol
HGNC:
MIR19B1
Description
Homo sapiens
hsa-mir-19b-1 precursor miRNA mir-19
Gene
family?
family?
RF00245;
mir-19
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR19B1 is a member of the miR-17~92 cluster and has been associated with various conditions and diseases. It has been linked to the presence of right renal agenesis [PMC9090243]. Additionally, MIR19B1, along with MIR17, MIR18A, and MIR20A, is part of the miR-17–92 cluster on chromosome 13 that is upregulated in lung cancer cell lines and involved in repression of proliferation inhibition and apoptotic agents [PMC6418160]. In the context of malignancy, MIR19B1 has been found to be one of the most upregulated miRNAs [PMC9390975]. In individuals with non-syndromic CAKUT (congenital anomalies of the kidney and urinary tract), pathogenic variants in MIR19B1 have been identified [PMC7998154]. The miR-17~92 cluster genes, including MIR19B1, have been found to be encompassed by a microduplication at 13q31.3 [PMC4005632]. The host gene for the miR-17~92 cluster is MIR17HG, which encodes for six individual miRNAs including MIR19B1 [PMC4005632]. Copy gains or amplifications affecting this locus have also been found to impact the miR17-92 cluster genes [PMC9259584]. References: [PMC9090243] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090243/ [PMC6418160] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418160/ [PMC9390975] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390975/ [PMC7998154] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998154/ [PMC4005632] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005632/ [PMC9259584] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259584/
Literature search
302 open access papers mention hsa-mir-19b-1
(1309 sentences)
(1309 sentences)
Sequence
871328
reads,
12712
reads per million, 152 experiments
cacuguucuaugguuAGUUUUGCAGGUUUGCAUCCAGCugugugauauucugcUGUGCAAAUCCAUGCAAAACUGAcugugguagug
(((((..(((((((((((((((((((((((((..((((.............)))))))))).)).))))))))))))))))))))))
(((((..(((((((((((((((((((((((((..((((.............)))))))))).)).))))))))))))))))))))))
Structure
uu - - UC ugugu
cacug cuaugguuAGUUUUGCA GG UUUGCA CAGC g
||||| ||||||||||||||||| || |||||| |||| a
gugau ggugucAGUCAAAACGU CC AAACGU GUcg u
-- A U -- ucuua
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr13: 91351192-91351278 [+]
Clustered miRNAs
5 other miRNAs are < 10 kb from hsa-mir-19b-1
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-19b-1 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-19b-1 is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-19b-1 is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-19b-1-5p
| Accession | MIMAT0004491 |
| Description | Homo sapiens hsa-miR-19b-1-5p mature miRNA |
| Sequence | 16 - AGUUUUGCAGGUUUGCAUCCAGC - 38 |
| Evidence |
experimental
cloned [8] |
| Database links |
|
| Predicted targets |
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Mature hsa-miR-19b-3p
| Accession | MIMAT0000074 |
| Description | Homo sapiens hsa-miR-19b-3p mature miRNA |
| Sequence | 54 - UGUGCAAAUCCAUGCAAAACUGA - 76 |
| Evidence |
experimental
cloned [1-3,6-9], Northern [1,5] |
| Database links |
|
| Predicted targets |
|
References
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