Accession
MI0000074
Symbol
HGNC:
MIR19B1
Description
Homo sapiens
hsa-mir-19b-1 precursor miRNA mir-19
Gene
family?
family?
RF00245;
mir-19
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR19B1 is a microRNA belonging to the miR-17~92 cluster located on chromosome 13, which plays a role in various biological processes, including development and cancer [PMC6418160]. This microRNA has been implicated in right renal agenesis, a developmental anomaly of the kidney [PMC9090243]. Additionally, MIR19B1 is one of the most upregulated miRNAs in malignancies, suggesting its involvement in cancerous processes [PMC9390975]. In the context of non-syndromic congenital anomalies of the kidney and urinary tract (CAKUT), MIR19B1 variants have been identified as potentially pathogenic [PMC7998154]. A microduplication including MIR19B1 has been detected at 13q31.3, which may have implications for renal development and disease [PMC4005632]. The host gene for this cluster, MIR17HG, encodes six individual miRNAs including MIR19B1; alterations in this locus have been associated with copy gains or amplifications that may affect gene function [PMC4005632; PMC9259584]..
Literature search
302 open access papers mention hsa-mir-19b-1
(1309 sentences)
(1309 sentences)
Sequence
871159
reads,
6763
reads per million, 152 experiments
cacuguucuaugguuAGUUUUGCAGGUUUGCAUCCAGCugugugauauucugcUGUGCAAAUCCAUGCAAAACUGAcugugguagug
(((((..(((((((((((((((((((((((((..((((.............)))))))))).)).))))))))))))))))))))))
(((((..(((((((((((((((((((((((((..((((.............)))))))))).)).))))))))))))))))))))))
Structure
uu - - UC ugugu
cacug cuaugguuAGUUUUGCA GG UUUGCA CAGC g
||||| ||||||||||||||||| || |||||| |||| a
gugau ggugucAGUCAAAACGU CC AAACGU GUcg u
-- A U -- ucuua
Annotation confidence
Medium
Do you think this miRNA is real?
Genome context
chr13: 91351192-91351278 [+]
Clustered miRNAs
5 other miRNAs are < 10 kb from hsa-mir-19b-1
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-19b-1 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-19b-1 is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-19b-1 is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-19b-1-5p
| Accession | MIMAT0004491 |
| Description | Homo sapiens hsa-miR-19b-1-5p mature miRNA |
| Sequence | 16 - AGUUUUGCAGGUUUGCAUCCAGC - 38 |
| Evidence |
experimental
cloned [8] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-19b-3p
| Accession | MIMAT0000074 |
| Description | Homo sapiens hsa-miR-19b-3p mature miRNA |
| Sequence | 54 - UGUGCAAAUCCAUGCAAAACUGA - 76 |
| Evidence |
experimental
cloned [1-3,6-9], Northern [1,5] |
| Database links |
|
| Predicted targets |
|
References
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