Accession
MI0000076
Symbol
HGNC:
MIR20A
Description
Homo sapiens
hsa-mir-20a precursor miRNA mir-17
Gene
family?
family?
RF00051;
mir-17
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR20A is a type of microRNA that is involved in mediating MYC and STAT3 dosage compensation through a redundant mechanism [PMC8627999]. In a study investigating regenerative therapy for jawbone atrophy, an atelocollagen-based gene-activated matrix (GAM) containing naked-pDNAs encoding MIR20A was used [PMC7955717]. The expression of MIR20A, along with other microRNAs, was assessed using RT-PCR and shown in Figure 4 [PMC9687337]. SNHG5, an upregulated gene, was found to reduce MIR20A expression and increase the expression of apoptosis proteins BECN1, ATG5, and ATG7 [PMC6912041]. Additionally, SNHG5 could interact with MIR32 to reduce the migration and proliferation effects of SNHG5 on gastric cancer cells [PMC6912041]. In a preliminary experiment using cultured MSCs, it was found that the delivery of MIR20A using an atelocollagen-based GAM had high transfection efficacy without cytotoxicity compared to commercial vectors such as a lentiviral vector [PMC7955717].
Literature search
463 open access papers mention hsa-mir-20a
(1949 sentences)
(1949 sentences)
Sequence
992364
reads,
6826
reads per million, 155 experiments
guagcacUAAAGUGCUUAUAGUGCAGGUAGuguuuaguuaucuACUGCAUUAUGAGCACUUAAAGuacugc
((((.(((.(((((((((((((((((.(((...........))))))))))))))))))))..))).))))
((((.(((.(((((((((((((((((.(((...........))))))))))))))))))))..))).))))
Structure
c -A G uguu
guag acU AAGUGCUUAUAGUGCAG UAG u
|||| ||| ||||||||||||||||| ||| a
cguc uGA UUCACGAGUAUUACGUC Auc g
a AA - uauu
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr13: 91351065-91351135 [+]
Clustered miRNAs
5 other miRNAs are < 10 kb from hsa-mir-20a
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-20a is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-20a is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-20a is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-20a-5p
| Accession | MIMAT0000075 |
| Description | Homo sapiens hsa-miR-20a-5p mature miRNA |
| Sequence | 8 - UAAAGUGCUUAUAGUGCAGGUAG - 30 |
| Evidence |
experimental
cloned [1,4-7], Northern [1] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-20a-3p
| Accession | MIMAT0004493 |
| Description | Homo sapiens hsa-miR-20a-3p mature miRNA |
| Sequence | 44 - ACUGCAUUAUGAGCACUUAAAG - 65 |
| Evidence |
experimental
cloned [6] |
| Database links |
|
| Predicted targets |
|
References
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