miRBase entry: hsa-mir-26a-1

Stem-loop hsa-mir-26a-1

Homo sapiens hsa-mir-26a-1 precursor miRNA
Gene family
MIPF0000043; mir-26

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR26A1 is a microRNA that has been implicated in various biological processes and diseases. It has been found that the rs7372209 T allele in MIR26A1 is associated with an increased risk of endometriosis, while the reference C allele is protective against endometriosis development. However, these associations were not significant after Bonferroni correction [PMC5363543]. In aggressive chronic lymphocytic leukemia (CLL), downregulation of EZH2, a gene involved in cell survival, is induced by overexpressing MIR26A1. This suggests a pro-survival role of EZH2 in aggressive CLL and an indirect effect of MYC reduction on the levels of negative regulators such as MIR26A1 [PMC6773411]. In CLL patients, there is a negative correlation between the expression of EZH2 and its negative regulators like MIR26A1 [PMC6773411]. Additionally, MIR26A1 has been found to be hypermethylated and silenced in CLL patients, leading to higher levels of EZH2 [PMC5652802]. It has also been shown that MIR26A1 can regulate TET1 at the transcriptional level by modulating the levels of EZH2 at the TET1 promoter [PMC5652802]. Overall, these findings highlight the role of MIR26A1 in various diseases and its interaction with genes like EZH2 and TET1.

Literature search
424 open access papers mention hsa-mir-26a-1
(1773 sentences)


2931049 reads, 11638 reads per million, 159 experiments

   g      U         C          gugcag 
||| |||||| ||||||||| ||||||||||      u
   a      C         U          guaacc 

Annotation confidence High
Do you think this miRNA is real?
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [6].

Genome context
chr3: 37969404-37969480 [+]

Disease association
hsa-mir-26a-1 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-26a-1 is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-26a-1 is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-26a-5p

Accession MIMAT0000082
Description Homo sapiens hsa-miR-26a-5p mature miRNA
Evidence experimental
cloned [2,4-7], Northern [3]
Database links
Predicted targets

Mature hsa-miR-26a-1-3p

Accession MIMAT0004499
Description Homo sapiens hsa-miR-26a-1-3p mature miRNA
Evidence experimental
cloned [6]
Database links
Predicted targets


  1. PubMed ID: 11679670
    Identification of novel genes coding for small expressed RNAs
    "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
    "Science (2001) 294:853-858

  2. PubMed ID: 15183728
    Human embryonic stem cells express a unique set of microRNAs
    "Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS"
    "Dev Biol (2004) 270:488-498

  3. PubMed ID: 14573789
    Reduced accumulation of specific microRNAs in colorectal neoplasia
    "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
    "Mol Cancer Res (2003) 1:882-891

  4. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  5. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  6. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  7. PubMed ID: 15978578
    Identification of human fetal liver miRNAs by a novel method
    "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
    "FEBS Lett (2005) 579:3849-3854