Accession
MI0000087
Symbol
HGNC:
MIR29A
Description
Homo sapiens
hsa-mir-29a precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR29A is a microRNA involved in various biological processes, including matrix remodeling and fibrosis, as indicated by its formation being primed by myocardin [PMC7123062]. In the context of lung cancer, MIR29A levels were found to be significantly lower in patients with non-small cell lung cancer (NSCLC) compared to small cell lung cancer (SCLC) [PMC9987486]. Additionally, MIR29A is differentially expressed in Parkinson's disease (PD) compared with vascular parkinsonism (VP), suggesting its potential role in disease-specific pathologies [PMC8407885]. However, its elevated expression has been associated with poor patient survival across various conditions, suggesting a prognostic role for MIR29A [PMC6368411]. In the liver, TGF-β1 may induce Fstl1 partially through the downregulation of MIR29A, and there appears to be a reciprocal regulatory relationship between Fstl1 and MIR29A in hepatic stellate cells (HSCs) [PMC7493388]. Furthermore, upregulation of MIR29A has been observed in breast cancer stem cells (BCSCs), aggressive breast cancer cell lines, and breast cancer tissues [PMC9102147], highlighting its potential involvement in tumor aggressiveness. Lastly, research on liver fibrosis has underscored the importance of MIR29A during the regression of this condition [PMC6412626].
Literature search
662 open access papers mention hsa-mir-29a
(3429 sentences)
(3429 sentences)
Sequence
2370837
reads,
7970
reads per million, 141 experiments
augACUGAUUUCUUUUGGUGUUCAGagucaauauaauuuucUAGCACCAUCUGAAAUCGGUUAu
((((((((((((...(((((((.((((...........)))))))))))...))))))))))))
((((((((((((...(((((((.((((...........)))))))))))...))))))))))))
Structure
UUU C ucaa
augACUGAUUUC UGGUGUU AGag u
|||||||||||| ||||||| |||| a
uAUUGGCUAAAG ACCACGA Ucuu u
UCU - uuaa
Annotation confidence
Medium
Do you think this miRNA is real?
Comments
miR-29a was previously know as miR-29 here and in [1]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [6].
Genome context
chr7: 130876747-130876810 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-29a
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-29a is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-29a-5p
| Accession | MIMAT0004503 |
| Description | Homo sapiens hsa-miR-29a-5p mature miRNA |
| Sequence | 4 - ACUGAUUUCUUUUGGUGUUCAG - 25 |
| Evidence |
experimental
cloned [6] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-29a-3p
| Accession | MIMAT0000086 |
| Description | Homo sapiens hsa-miR-29a-3p mature miRNA |
| Sequence | 42 - UAGCACCAUCUGAAAUCGGUUA - 63 |
| Evidence |
experimental
cloned [1-3,5-7], Northern [1,4], Illumina [8] |
| Database links |
|
| Predicted targets |
|
References
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