Accession
MI0000087
Symbol
HGNC:
MIR29A
Description
Homo sapiens
hsa-mir-29a precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR29A is a microRNA that is involved in various biological processes and diseases. It is a type of non-coding RNA that regulates gene expression. One study found that MIR29A, along with miR24, is primed by myocardin and plays a role in atherosclerosis retardation and matrix remodeling and fibrosis [PMC7123062]. In patients with non-small cell lung cancer (NSCLC), MIR29A levels were significantly lower compared to patients with small cell lung cancer (SCLC) [PMC9987486]. Additionally, MIR29A was found to be differentially expressed in pancreatic ductal (PD) compared to viral pancreatitis (VP) specimens, along with miR-23a and miR181c [PMC8407885]. The expression of MIR29A was also associated with patient prognosis, where elevated expression of certain microRNAs including MIR29A was correlated with poor patient survival [PMC6368411]. In liver fibrosis, TGF-β1 was found to downregulate MIR29A, potentially inducing the expression of Fstl1 [PMC7493388]. Furthermore, MIR29A has been found to be upregulated in breast cancer stem cells (BCSCs), aggressive breast cancer cell lines, and breast cancer tissues [PMC9102147]. Finally, the importance of MIR29A during the regression of liver fibrosis has been highlighted in a study [PMC6412626]. Overall, these findings demonstrate the diverse roles of MIR29A in various diseases and biological processes.
Literature search
662 open access papers mention hsa-mir-29a
(3429 sentences)
(3429 sentences)
Sequence
2370837
reads,
9609
reads per million, 141 experiments
augACUGAUUUCUUUUGGUGUUCAGagucaauauaauuuucUAGCACCAUCUGAAAUCGGUUAu
((((((((((((...(((((((.((((...........)))))))))))...))))))))))))
((((((((((((...(((((((.((((...........)))))))))))...))))))))))))
Structure
UUU C ucaa
augACUGAUUUC UGGUGUU AGag u
|||||||||||| ||||||| |||| a
uAUUGGCUAAAG ACCACGA Ucuu u
UCU - uuaa
Annotation confidence
High
Do you think this miRNA is real?
Comments
miR-29a was previously know as miR-29 here and in [1]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [6].
Genome context
chr7: 130876747-130876810 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-29a
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-29a is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-29a-5p
| Accession | MIMAT0004503 |
| Description | Homo sapiens hsa-miR-29a-5p mature miRNA |
| Sequence | 4 - ACUGAUUUCUUUUGGUGUUCAG - 25 |
| Evidence |
experimental
cloned [6] |
| Database links |
|
| Predicted targets |
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Mature hsa-miR-29a-3p
| Accession | MIMAT0000086 |
| Description | Homo sapiens hsa-miR-29a-3p mature miRNA |
| Sequence | 42 - UAGCACCAUCUGAAAUCGGUUA - 63 |
| Evidence |
experimental
cloned [1-3,5-7], Northern [1,4], Illumina [8] |
| Database links |
|
| Predicted targets |
|
References
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