Accession
MI0000103
Symbol
HGNC:
MIR101-1
Description
Homo sapiens
hsa-mir-101-1 precursor miRNA
Gene family
MIPF0000046;
mir-101
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR101-1 is a microRNA-containing precursor that has been found to decrease significantly in LT and Ar compared to IBA in various brain regions [PMC7848201]. It is one of the miRNA precursors that showed the highest fold-changes in expression [PMC7848201]. MIR101-1 is also included in the top-ranked miRNA expression signatures [PMC9284388]. It has been identified as one of the differentially expressed genes (DEGs) related to Th2 cells and MAIT cells [PMC9380889]. The G-allele of rs11594111 extends the continuous complementary sequence to MIR101-1 from 7 nucleotides to 11 nucleotides [PMC3198095]. However, SUV39H2 mRNA is not predicted to be a target for MIR101-1 [PMC3198095]. In small RNA-seq datasets, MIR101-1 has uniquely aligned read pairs, while its paralogue MIR101-2 does not have any assigned read pairs [PMC6901076]. In Parkinson's disease patients, MIR101-1 has been found to be notably down-regulated along with other miRNAs such as miR-133b, miR218-2, and miR107 [PMC5288660]. References: [PMC7848201] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848201/ [PMC9284388] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284388/ [PMC9380889] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380889/ [PM3198095] - https://www.ncbi.nlm.nih.gov/pmc/articles/PM3198095/ [PM6901076] - https://www.ncbi.nlm.nih.gov/pmc/articles/PM6901076/ [PMC5288660] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288660/
Literature search
307 open access papers mention hsa-mir-101-1
(2239 sentences)
(2239 sentences)
Sequence
1180657
reads,
3806
reads per million, 145 experiments
ugcccuggcuCAGUUAUCACAGUGCUGAUGCUgucuauucuaaaggUACAGUACUGUGAUAACUGAAggauggca
((((.....((((((((((((((((((.((((............)))))))))))))))))))))).....))))
((((.....((((((((((((((((((.((((............)))))))))))))))))))))).....))))
Structure
cuggc A gucua
ugcc uCAGUUAUCACAGUGCUG UGCU u
|||| |||||||||||||||||| ||||
acgg AGUCAAUAGUGUCAUGAC AUgg u
uaggA - aaauc
Annotation confidence
High
Do you think this miRNA is real?
Comments
Reference [1] reports two miR-101 precursor hairpin structures in human, on chromosome 1 (MIR:MI0000103) and 9 (MIR:MI0000739, named mir-101-precursor-9 in [1]). The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].
Genome context
chr1: 65058434-65058508 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-101-1
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-101-1 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-101-5p
| Accession | MIMAT0004513 |
| Description | Homo sapiens hsa-miR-101-5p mature miRNA |
| Sequence | 11 - CAGUUAUCACAGUGCUGAUGCU - 32 |
| Evidence |
experimental
cloned [3-4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-101-3p
| Accession | MIMAT0000099 |
| Description | Homo sapiens hsa-miR-101-3p mature miRNA |
| Sequence | 47 - UACAGUACUGUGAUAACUGAA - 67 |
| Evidence |
experimental
cloned [1-4] |
| Database links |
|
| Predicted targets |
|
References
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