miRBase entry: dme-mir-14

Stem-loop dme-mir-14


Accession
MI0000136
Description
Drosophila melanogaster dme-mir-14 precursor miRNA mir-14
Gene
family?
RF00752; mir-14

Literature search
24 open access papers mention dme-mir-14
(170 sentences)

Sequence

1647277 reads, 52805 reads per million, 49 experiments
uguGGGAGCGAGACGGGGACUCACUgugcuuauuaaauagUCAGUCUUUUUCUCUCUCCUAUa
((((((((.((((.(((((((.(((((.........))))).))))))).)))).))))))))

Structure
        C    C       C     gcu 
uguGGGAG GAGA GGGGACU ACUgu   u
|||||||| |||| ||||||| |||||   a
aUAUCCUC CUCU UUUCUGA Ugaua   u
        U    U       C     aau 


Annotation confidence High
Do you think this miRNA is real?
Comments
miR-14 has been reported to act as a cell death repressor and regulator of fat metabolism [2].

Genome context
chr2R: 9553762-9553824 [+]

Database links

Mature dme-miR-14-3p

Accession MIMAT0000120
Description Drosophila melanogaster dme-miR-14-3p mature miRNA
Sequence 41 - UCAGUCUUUUUCUCUCUCCUAU - 62
Evidence experimental
cloned [1,4], Northern [3], 454 [5-6], Illumina [6]
Database links
Predicted targets

Mature dme-miR-14-5p

Accession MIMAT0020798
Description Drosophila melanogaster dme-miR-14-5p mature miRNA
Sequence 4 - GGGAGCGAGACGGGGACUCACU - 25
Evidence not_experimental
Database links

References

  1. PubMed ID: 11679670
    Identification of novel genes coding for small expressed RNAs
    "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
    "Science (2001) 294:853-858

  2. PubMed ID: 12812784
    Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and broad-Complex gene activity
    "Sempere LF, Sokol NS, Dubrovsky EB, Berger EM, Ambros V"
    "Dev Biol (2003) 259:9-18

  3. PubMed ID: 12919683
    The small RNA profile during Drosophila melanogaster development
    "Aravin AA, Lagos-Quintana M, Yalcin A, Zavolan M, Marks D, Snyder B, Gaasterland T, Meyer J, Tuschl T"
    "Dev Cell (2003) 5:337-350

  4. PubMed ID: 17989254
    Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs
    "Ruby JG, Stark A, Johnston WK, Kellis M, Bartel DP, Lai EC"
    "Genome Res (2007) 17:1850-1864

  5. PubMed ID: 17989255
    Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes
    "Stark A, Kheradpour P, Parts L, Brennecke J, Hodges E, Hannon GJ, Kellis M"
    "Genome Res (2007) 17:1865-1879

  6. PubMed ID: 12725740
    The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism
    "Xu P, Vernooy SY, Guo M, Hay BA"
    "Curr Biol (2003) 13:790-795