Stem-loop mmu-mir-99a

Accession

MI0000146

Symbol

MGI: Mir99a

Description

Mus musculus mmu-mir-99a precursor miRNA

Literature search

66 open access papers mention mmu-mir-99a
(778 sentences)

Sequence

414559 reads, 1438 reads per million, 107 experiments

cauaAACCCGUAGAUCCGAUCUUGUGgugaaguggaccgcgCAAGCUCGUUUCUAUGGGUCUgug
((((.(((((((((..(((.((((((((.......)))..))))).)))..))))))))).))))

Structure

    A         UC   U     --   ga 
caua ACCCGUAGA  CGA CUUGU  Ggu  a
|||| |||||||||  ||| |||||  |||  g
gugU UGGGUAUCU  GCU GAACg  cca  u
    C         UU   C     cg   gg 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context

chr16: 77598936-77599000 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from mmu-mir-99a

Mature mmu-miR-99a-5p

• Accession: MIMAT0000131
• Description: Mus musculus mmu-miR-99a-5p mature miRNA
• Sequence: 5 - AACCCGUAGAUCCGAUCUUGUG - 26
• Evidence: experimental ; cloned [1-3], Illumina [4-5]

Mature mmu-miR-99a-3p

• Accession: MIMAT0016981
• Description: Mus musculus mmu-miR-99a-3p mature miRNA
• Sequence: 42 - CAAGCUCGUUUCUAUGGGUCU - 62
• Evidence: experimental ; Illumina [5]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739


3. PubMed ID: 16766679
   Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes
   "Watanabe T, Takeda A, Tsukiyama T, Mise K, Okuno T, Sasaki H, Minami N, Imai H"
   "Genes Dev (2006) 20:1732-1743


4. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


5. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009