Stem-loop mmu-mir-125a

Accession

MI0000151

Symbol

MGI: Mir125a

Description

Mus musculus mmu-mir-125a precursor miRNA

Literature search

198 open access papers mention mmu-mir-125a
(1294 sentences)

Sequence

2388628 reads, 3406 reads per million, 105 experiments

cugggUCCCUGAGACCCUUUAACCUGUGAggacguccagggucACAGGUGAGGUUCUUGGGAGCCugg
((((((.(((((((.((((..((((((((...(.....)..)))))))))))).))))))).))))))

Structure

      C       C    UA        gga g 
cugggU CCUGAGA CCUU  ACCUGUGA   c u
|||||| ||||||| ||||  ||||||||   | c
gguCCG GGGUUCU GGAG  UGGACAcu   g c
      A       U    --        -gg a 

Annotation confidence Medium

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chr17: 17830812-17830879 [+]

Clustered miRNAs

2 other miRNAs are < 10 kb from mmu-mir-125a

Mature mmu-miR-125a-5p

• Accession: MIMAT0000135
• Description: Mus musculus mmu-miR-125a-5p mature miRNA
• Sequence: 6 - UCCCUGAGACCCUUUAACCUGUGA - 29
• Evidence: experimental ; cloned [1-2], Illumina [3-4]

Mature mmu-miR-125a-3p

• Accession: MIMAT0004528
• Description: Mus musculus mmu-miR-125a-3p mature miRNA
• Sequence: 44 - ACAGGUGAGGUUCUUGGGAGCC - 65
• Evidence: experimental ; cloned [2], Illumina [3-4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739


3. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


4. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009