Stem-loop mmu-mir-125b-2

Accession

MI0000152

Symbol

MGI: Mir125b-2

Description

Mus musculus mmu-mir-125b-2 precursor miRNA

Literature search

260 open access papers mention mmu-mir-125b-2
(1514 sentences)

Sequence

1708265 reads, 9402 reads per million, 104 experiments

gccuagUCCCUGAGACCCUAACUUGUGAgguauuuuaguaacaucACAAGUCAGGUUCUUGGGACCUaggc
((((((((((.((((.(((.((((((((.((.........)).)))))))).))).)))))))).))))))

Structure

      -    U    C   A        g  auu 
gccuag UCCC GAGA CCU ACUUGUGA gu   u
|||||| |||| |||| ||| |||||||| ||   u
cggaUC AGGG UUCU GGA UGAACAcu ca   a
      C    -    U   C        a  aug 

Annotation confidence Medium

Comments

Mouse miR-125b was cloned from mouse brain tissues in [1]. There are 2 predicted hairpin precursor structures in the mouse genome, each has a closely related human homologue [2] (mir-125b-1, MIR:MI0000725; mir-125b-2, MIR:MI0000152; the latter was previously named mir-125b here).

Genome context

chr16: 77646273-77646343 [+]

Mature mmu-miR-125b-5p

• Accession: MIMAT0000136
• Description: Mus musculus mmu-miR-125b-5p mature miRNA
• Sequence: 7 - UCCCUGAGACCCUAACUUGUGA - 28
• Evidence: experimental ; cloned [1,3-4], Illumina [5-6]

Mature mmu-miR-125b-2-3p

• Accession: MIMAT0004529
• Description: Mus musculus mmu-miR-125b-2-3p mature miRNA
• Sequence: 46 - ACAAGUCAGGUUCUUGGGACCU - 67
• Evidence: experimental ; cloned [4], Illumina [5-6]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739


3. PubMed ID: 16766679
   Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes
   "Watanabe T, Takeda A, Tsukiyama T, Mise K, Okuno T, Sasaki H, Minami N, Imai H"
   "Genes Dev (2006) 20:1732-1743


4. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


5. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


6. PubMed ID: 15634332
   New human and mouse microRNA genes found by homology search
   "Weber MJ"
   "FEBS J (2005) 272:59-73