Stem-loop mmu-mir-10b

Accession

MI0000221

Symbol

MGI: Mir10b

Description

Mus musculus mmu-mir-10b precursor miRNA

Literature search

133 open access papers mention mmu-mir-10b
(861 sentences)

Sequence

13785945 reads, 20752 reads per million, 97 experiments

uauaUACCCUGUAGAACCGAAUUUGUGugguacccacauagucaCAGAUUCGAUUCUAGGGGAAUAua
(((((.((((.(((((.(((((((((((((...))))......))))))))).))))))))).)))))

Structure

     A    G     C         ------    u 
uauaU CCCU UAGAA CGAAUUUGU      Gugg  
||||| |||| ||||| |||||||||      |||| a
auAUA GGGG AUCUU GCUUAGACa      cacc  
     A    -     A         cugaua    c 

Annotation confidence Low

Comments

The sequence of mouse miR-10b, as reported by Lagos-Quintana et al. [1], is offset by 2 nt in the 3' direction with respect to sequences cloned from human (MIR:MI0000267) and zebrafish (MIR:MI0001364). The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context

chr2: 74726070-74726137 [+]

Mature mmu-miR-10b-5p

• Accession: MIMAT0000208
• Description: Mus musculus mmu-miR-10b-5p mature miRNA
• Sequence: 5 - UACCCUGUAGAACCGAAUUUGUG - 27
• Evidence: experimental ; cloned [1-2], Illumina [3-4]

Mature mmu-miR-10b-3p

• Accession: MIMAT0004538
• Description: Mus musculus mmu-miR-10b-3p mature miRNA
• Sequence: 45 - CAGAUUCGAUUCUAGGGGAAUA - 66
• Evidence: experimental ; cloned [2], Illumina [3-4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12554859
   New microRNAs from mouse and human
   "Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T"
   "RNA (2003) 9:175-179


3. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


4. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009