miRBase entry: hsa-mir-192

Stem-loop hsa-mir-192

Homo sapiens hsa-mir-192 precursor miRNA
Gene family
MIPF0000063; mir-192

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR192 is a specific miRNA that has been found to be increased in the renal cortex of diabetic mice compared to control mice [PMC5376412]. It is also considered a biomarker for heart failure, along with miR34a and miR-194, and is released by exosomes [PMC8773242]. These specific miRNAs, including MIR192, are being studied for their potential use in the early diagnosis of hypertrophic cardiomyopathy and heart failure [PMC8773242]. Exosomes are small vesicles that are released by cells and contain various biomolecules, including miRNAs [PMC8773242]. The levels of TGF-β1, p53, and MIR192 were found to be increased in the renal cortex of diabetic mice compared to control mice in a study [PMC5376412]. These findings suggest that MIR192 may play a role in the pathogenesis of diabetes-related renal complications. Additionally, the release of MIR192 by exosomes suggests its potential as a biomarker for heart failure. Further research is needed to fully understand the role of MIR192 in these conditions and its potential as a diagnostic tool.

Literature search
214 open access papers mention hsa-mir-192
(1094 sentences)


856572 reads, 1383 reads per million, 125 experiments

gccgagacc   u  --   g g  C         -     A       ugcucuc 
         gag gc  aca g cu UGACCUAUG AAUUG CAGCCag       g
         ||| ||  ||| | || ||||||||| ||||| |||||||        
         cuc cg  ugu u GA ACUGGAUAC UUAAC GUCgguc       u
cgaccguaa   -  cu   a g  C         C     C       uccccuc 

Annotation confidence High
Do you think this miRNA is real?
Lagos-Quintana et al. validated the presence of an 18 nt excised sequence by cloning [1]. Lim et al. predicted the miR by computational methods using conservation with mouse and Fugu rubripes sequences. Expression of the excised miR was validated in zebrafish, and the 5' end mapped by PCR [2]. The 3' ends of the reported sequences differ by 3 nt - this entry contains the longer sequence. Lim et al. report three separate copies of this gene named mir-192-1, -2 and -3 based on 2001 human genome assemblies [2]. Subsequent assemblies suggest the presence of only one gene located on chromosome 11.

Genome context
chr11: 64891137-64891246 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-192
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-192 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-192-5p

Accession MIMAT0000222
Description Homo sapiens hsa-miR-192-5p mature miRNA
Evidence experimental
cloned [3-4]
Database links
Predicted targets

Mature hsa-miR-192-3p

Accession MIMAT0004543
Description Homo sapiens hsa-miR-192-3p mature miRNA
Evidence experimental
cloned [4]
Database links
Predicted targets


  1. PubMed ID: 14573789
    Reduced accumulation of specific microRNAs in colorectal neoplasia
    "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
    "Mol Cancer Res (2003) 1:882-891

  2. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  3. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540

  4. PubMed ID: 12554859
    New microRNAs from mouse and human
    "Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T"
    "RNA (2003) 9:175-179