miRBase entry: hsa-mir-7-1

Stem-loop hsa-mir-7-1

Homo sapiens hsa-mir-7-1 precursor miRNA
Gene family
MIPF0000022; mir-7

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR7-1 is a microRNA precursor that is generated from HNRNPK intron 15 [PMC4647676]. Further research is needed to understand the genetic regulation and expression of MIR7-1, as well as its role in metabolic traits [PMC9522793]. MIR7-1 is located in the last intron of the HNRNPK gene, and its expression is driven by the promoter of HNRNPK [PMC9522793]. The transcription factor FOXP3 positively regulates miR-7 expression in breast cancer [PMC4600152]. miR-7 can be expressed from three loci in humans, including MIR7-1 [PMC4600152]. The exact mechanism of miR-7 stimulation via the PI3K/Akt pathway is still unknown, but c-Myc has been found to directly bind and stimulate expression from the MIR7-1 promoter [PMC4600152]. Other transcription factors, such as HOXD10 and HNF4α, have also been involved in promoting miR-7 expression via interaction with the promoter regions of miR-7 genes including MIR7-1 [PMC4600152]. MIR7-1 is believed to be the most highly expressed source of mature miR-7 and is located within the hnRNPK gene on chromosome 9 [PMC4600152]. In addition to its role in breast cancer, MIR7-1 has also been implicated in other diseases such as neurodegenerative alterations and metabolic alterations [PMC9571148].

Literature search
342 open access papers mention hsa-mir-7-1
(2084 sentences)


936086 reads, 6676 reads per million, 153 experiments

--u    u  -      a  u        A     A       U      --     a 
   ugga gu uggccu gu cugugUGG AGACU GUGAUUU GUUGUU  uuuag u
   |||| || |||||| || |||||||| ||||| ||||||| ||||||  |||||  
   aucu cg accgga ca gguAUACC UCUGA CACUAAA CAACag  aaauc a
gac    c  u      -  c        G     -       -      cu     a 

Annotation confidence High
Do you think this miRNA is real?
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. Landgraf et al. confirm expression in human [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context
chr9: 83969748-83969857 [-]

Disease association
hsa-mir-7-1 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-7-5p

Accession MIMAT0000252
Description Homo sapiens hsa-miR-7-5p mature miRNA
Evidence experimental
cloned [2-3]
Database links
Predicted targets

Mature hsa-miR-7-1-3p

Accession MIMAT0004553
Description Homo sapiens hsa-miR-7-1-3p mature miRNA
Evidence experimental
cloned [2]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540