Stem-loop hsa-mir-7-2

Accession

MI0000264

Symbol

HGNC: MIR7-2

Description

Homo sapiens hsa-mir-7-2 precursor miRNA

Literature search

341 open access papers mention hsa-mir-7-2
(2076 sentences)

Sequence

926760 reads, 2873 reads per million, 159 experiments

cuggauacagaguggaccggcuggccccaucUGGAAGACUAGUGAUUUUGUUGUUgucuuacugcgcucaaCAACAAAUCCCAGUCUACCUAAuggugccagccaucgca
(((....))).((((...(((((((.((((..((.(((((.(.(((((.(((((((............))))))))))))).))))).))..)))).))))))).)))).

Structure

cuggauacaga    acc       c    cU  A     A U     U       ucuua 
           gugg   ggcuggc ccau  GG AGACU G GAUUU GUUGUUg     c
           ||||   ||||||| ||||  || ||||| | ||||| |||||||      
           cgcu   ccgaccg gguA  CC UCUGA C CUAAA CAACaac     u
----------a    --a       u    AU  A     C -     -       ucgcg 

Annotation confidence High

Comments

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. Landgraf et al. confirm expression in human [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chr15: 88611825-88611934 [+]

Clustered miRNAs

2 other miRNAs are < 10 kb from hsa-mir-7-2

Disease association

hsa-mir-7-2 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-7-5p

• Accession: MIMAT0000252
• Description: Homo sapiens hsa-miR-7-5p mature miRNA
• Sequence: 32 - UGGAAGACUAGUGAUUUUGUUGUU - 55
• Evidence: experimental ; cloned [2-3]

Mature hsa-miR-7-2-3p

• Accession: MIMAT0004554
• Description: Homo sapiens hsa-miR-7-2-3p mature miRNA
• Sequence: 72 - CAACAAAUCCCAGUCUACCUAA - 93
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 12624257
   Vertebrate microRNA genes
   "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
   "Science (2003) 299:1540