miRBase entry: hsa-mir-7-2

Stem-loop hsa-mir-7-2

Homo sapiens hsa-mir-7-2 precursor miRNA
Gene family
MIPF0000022; mir-7

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR7-2 is a genomic locus that has been reported to have a functional role in hepatic lipid homeostasis and is involved in peroxisome proliferator-activated receptor regulation [PMC6591351]. It is one of the candidate genes, along with MIR6672, MIR1720, MIR3529, MIR1571, MIR1560, MIR1785, MIR6662, MIR7454, MIR10A, MIR6663, MIR1735, and MIR6547 [PMC6591351]. In humans, the miR-7-encoding genes (MIR7-1, MIR7-2, and MIR7-3) produce primary miRNAs that are processed into pre-miRNAs and finally into the same mature miR-7 [PMC6479198]. The mouse gene equivalent to human's MIR7-2 was aligned against the human reference genome (GRCh38) using BLAT and BLASTN tools in the Ensembl database [PMC6479198]. The sequence of the mouse gene was found in the intergenic region on chromosome 15 [PMC8004586]. qRT-PCR analysis has validated mature miR-7 as a peroxisome proliferator-activated receptor-alpha (PPAR-alpha)-regulated miRNA in humans derived from three separate loci in the genome (MIR7-1, MIR7-2, and MIR7-3) [PMC5762714]. Transcription factors such as Forkhead box P3 (FOXP3), RELA (v-rel avian reticuloendotheliosis viral oncogene homolog A), homeobox D10 (HOXD10), and Hepatocyte Nuclear Factor 4 alpha (HNF4α) have been found to regulate miR-7 expression by interacting with promoter regions of different miR-7 genes [PMC7918072'>PMC4600152][PMC7918072[PMC7918072]. The transcription of MIR7-1 may be activated by c-Myc [PMC7918072]. MIR7-1, MIR7-2, and MIR7-3 are encoded by genes located on chromosomes 9q21, 15q26, and 19q13, respectively [PMC7918072]. The regulation of transcription for each locus proceeds separately [PMC7918072].

Literature search
341 open access papers mention hsa-mir-7-2
(2076 sentences)


926786 reads, 6424 reads per million, 159 experiments

cuggauacaga    acc       c    cU  A     A U     U       ucuua 
           gugg   ggcuggc ccau  GG AGACU G GAUUU GUUGUUg     c
           ||||   ||||||| ||||  || ||||| | ||||| |||||||      
           cgcu   ccgaccg gguA  CC UCUGA C CUAAA CAACaac     u
----------a    --a       u    AU  A     C -     -       ucgcg 

Annotation confidence High
Do you think this miRNA is real?
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. Landgraf et al. confirm expression in human [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context
chr15: 88611825-88611934 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-7-2
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-7-2 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-7-5p

Accession MIMAT0000252
Description Homo sapiens hsa-miR-7-5p mature miRNA
Evidence experimental
cloned [2-3]
Database links
Predicted targets

Mature hsa-miR-7-2-3p

Accession MIMAT0004554
Description Homo sapiens hsa-miR-7-2-3p mature miRNA
Evidence experimental
cloned [2]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540