Stem-loop hsa-mir-7-3

Accession

MI0000265

Symbol

HGNC: MIR7-3

Description

Homo sapiens hsa-mir-7-3 precursor miRNA

Literature search

345 open access papers mention hsa-mir-7-3
(2053 sentences)

Sequence

1580260 reads, 3003.0 reads per million, 163 experiments

agauuagaguggcuguggucuagugcugugUGGAAGACUAGUGAUUUUGUUGUUcugauguacuacgaCAACAAGUCACAGCCGGCCUCAUagcgcagacucccuucgac
......(((.((....(((((.((((((((.((..(.((.(((((((.((((((.((......)).))))))))))))))).)..)).))))))))))))))).)))...

Structure

agauua   u  cugu     a        U  AA A  A       U      c  au 
      gag gg    ggucu gugcugug GG  G CU GUGAUUU GUUGUU ug  g
      ||| ||    ||||| |||||||| ||  | || ||||||| |||||| ||   
      cuu cc    ucaga cgcgaUAC CC  C GA CACUGAA CAACag au  u
---cag   c  ----     -        U  GG C  -       -      c  ca 

Annotation confidence High

Comments

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. Expression in human was later verified by cloning [1,2].

Genome context

chr19: 4770670-4770779 [+]

Disease association

hsa-mir-7-3 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-7-5p

• Accession: MIMAT0000252
• Description: Homo sapiens hsa-miR-7-5p mature miRNA
• Sequence: 31 - UGGAAGACUAGUGAUUUUGUUGUU - 54
• Evidence: experimental ; cloned [2-3]

Mature hsa-miR-7-3-3p

• Accession: MIMAT0050493
• Description: Homo sapiens hsa-miR-7-3-3p mature miRNA
• Sequence: 69 - CAACAAGUCACAGCCGGCCUCAU - 91
• Evidence: experimental ; cloned [2-3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 12624257
   Vertebrate microRNA genes
   "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
   "Science (2003) 299:1540