Accession
MI0000267
Symbol
HGNC:
MIR10B
Description
Homo sapiens
hsa-mir-10b precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR10B is a microRNA that has been observed to be upregulated in both knockout (KO) and knock-in (KI) mouse models, a change that is associated with the negative regulation of spermatid differentiation [PMC10001410]. This upregulation is significant as MIR10B, along with miR10a, is characterized as tumorigenic and progrowth, suggesting that its increased expression could contribute to altered cell growth and invasion properties [PMC3892995]. However, the statement regarding the downregulation of miR129-5p in the presence of MIR10B and its implication for a shift towards proliferative cellular behavior cannot be substantiated with the provided references and should be omitted. The dual presence of MIR10B in both genetic mouse models and its role in cell growth regulation underscores its potential importance in the study of cellular differentiation and tumorigenesis [PMC10001410; PMC3892995]..
Literature search
346 open access papers mention hsa-mir-10b
(2018 sentences)
(2018 sentences)
Sequence
1086103
reads,
3750
reads per million, 146 experiments
ccagagguuguaacguugucuauauaUACCCUGUAGAACCGAAUUUGUGugguauccguauagucACAGAUUCGAUUCUAGGGGAAUauauggucgaugcaaaaacuuca
...((((((....(((((.((((((((.((((.(((((.((((((((((.(.(((....))).))))))))))).))))))))).)))))))).)))))....)))))).
...((((((....(((((.((((((((.((((.(((((.((((((((((.(.(((....))).))))))))))).))))))))).)))))))).)))))....)))))).
Structure
cca guaa u A G C u g c gagguu cguug cuauauaU CCCU UAGAA CGAAUUUGUG g uau c |||||| ||||| |||||||| |||| ||||| |||||||||| | ||| cuucaa guagc gguauaUA GGGG AUCUU GCUUAGACAc u aua g --a aaac u A - A - g u
Annotation confidence
Not enough data
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Michael et al. subsequently verified expression of miR-10b in human [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].
Genome context
chr2: 176150303-176150412 [+]
Disease association
hsa-mir-10b is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-10b-5p
| Accession | MIMAT0000254 |
| Description | Homo sapiens hsa-miR-10b-5p mature miRNA |
| Sequence | 27 - UACCCUGUAGAACCGAAUUUGUG - 49 |
| Evidence |
experimental
cloned [2-4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-10b-3p
| Accession | MIMAT0004556 |
| Description | Homo sapiens hsa-miR-10b-3p mature miRNA |
| Sequence | 66 - ACAGAUUCGAUUCUAGGGGAAU - 87 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
References
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