miRBase entry: hsa-mir-34a

Stem-loop hsa-mir-34a

Homo sapiens hsa-mir-34a precursor miRNA
Gene family
MIPF0000039; mir-34

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR34A is found to be downregulated in gastric cancer cell lines, such as BGC-823, compared to normal gastric epithelium cell lines [PMC4650715]. It has been suggested that MYCN downregulates MIR34A, similar to the action of c-Myc in colon carcinoma cells [PMC6048510]. MIR34A upregulation in T cells may explain the increased induction and activated state of T cells [PMC5351619]. The expression patterns of mature MIR34A differ from pri-MIR34A in METTL3-knockdown and METTL3-overexpressing cells [PMC7347714]. MIR34A is needed to repress Lef-1 post-transcriptionally along with miR-223 [PMC6282069]. The head-to-head orientation of the MIR34A HG and lncTAM34a allows for direct binding and targeting by sequence complementarity between the RNA and promoter DNA [PMC6030072]. Disruption of both TP53 and MIR34A is associated with poor survival in cancer patients [PMC4039115]. MIR34A negatively regulates dendrite outgrowth, while miR-124 positively regulates axonal and dendritic branching [PMC5928558]. The regulation of MHC-I by MIR34A in hippocampal neurons still needs further investigation [PMC7655649]. Co-administration of MIR34A with Dox inhibits invasion and migration in breast cancer cells [PMC8463267]..\

Literature search
927 open access papers mention hsa-mir-34a
(9143 sentences)


47919 reads, 442 reads per million, 147 experiments

-    -a  --    -         uU        -   A          -guga  a 
 ggcc  gc  ugug aguguuucu  GGCAGUGU CUU GCUGGUUGUu     gc a
 ||||  ||  |||| |||||||||  |||||||| ||| ||||||||||     ||  
 ccgg  ug  gcac ucgugaaga  CCGUCAUA GAA CGACUAACga     ug u
c    gg  uu    g         UC        U   -          aggaa  a 

Annotation confidence High
Do you think this miRNA is real?
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Dostie et al. independently cloned this sequence in human but misnamed the sequence miR-172 (the sequence is unrelated to MIR172 from Arabidopsis) [2]. The sequence maps to human chromosome 1. Human miR-34a was previously named miR-34 here and in [1], but is renamed to clarify homology with the alternatively named mouse sequence (MIR:MI0000584). The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context
chr1: 9151668-9151777 [-]

Disease association
hsa-mir-34a is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-34a is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-34a is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-34a-5p

Accession MIMAT0000255
Description Homo sapiens hsa-miR-34a-5p mature miRNA
Evidence experimental
cloned [2-4]
Database links
Predicted targets

Mature hsa-miR-34a-3p

Accession MIMAT0004557
Description Homo sapiens hsa-miR-34a-3p mature miRNA
Evidence experimental
cloned [3]
Database links
Predicted targets


  1. PubMed ID: 12554860
    Numerous microRNPs in neuronal cells containing novel microRNAs
    "Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G"
    "RNA (2003) 9:180-186

  2. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  3. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  4. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540