Accession
MI0000269
Symbol
HGNC:
MIR181A2
Description
Homo sapiens
hsa-mir-181a-2 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR181A2 is a microRNA that can be transcribed from two different genes, MIR181A1 and MIR181A2, and is regulated by multiple transcription factors and enhancer/promoter regions [PMC8979821]. Overexpression of MIR181A2 has been associated with various types of cancer [PMC6781644]. In a hyperglycemic state, the lncRNA MIR181A2 is downregulated, leading to an increase in the concentration of certain microRNAs [PMC9430013]. Overexpression of MIR181A2 has been shown to downregulate PCAF mRNA and protein levels [PMC5573355]. The downregulation of MIR181A2 by HIV vEnv glycoprotein is associated with enhanced viral transcription and infectivity [PMC5573355]. Lentiviral particles expressing MIR181A2 have been used to transduce T cells, resulting in reduced HIV transcription [PMC5573355]. The downregulation of MIR181A2 may be a natural host mechanism targeted by HIV to activate viral transcription [PMC5573355]. The host gene for MIR181A2, known as MIR181A2HG, has been found to be overexpressed in the thyroid but its function remains unknown [PMC6380385]. The expression levels of AKT2 have been investigated as potential targets for miR-181-3p and miR-181-5p derived from the host gene MIR18IAHG [PMC7891834]. In various tissues, including the human body's nucleus, the host gene for MIRA18IAHG is expressed [PMC10111190]. In different studies, miR-18IAHG has shown potential as a biomarker for certain diseases such as diabetes and cancer but its function remains unclear in these contexts.
Literature search
487 open access papers mention hsa-mir-181a-2
(2580 sentences)
(2580 sentences)
Sequence
2190059
reads,
4211
reads per million, 140 experiments
agaagggcuaucaggccagccuucagaggacuccaaggAACAUUCAACGCUGUCGGUGAGUuugggauuugaaaaaACCACUGACCGUUGACUGUACCuugggguccuua
.((((((((....)))...))))).(((((((((((((.(((.((((((..(((((((.((((...........))))))))))))))))).))).))))))))))))).
.((((((((....)))...))))).(((((((((((((.(((.((((((..(((((((.((((...........))))))))))))))))).))).))))))))))))).
Structure
agaagggcuaucaggccagccuuca A U CU A ggga
gaggacuccaagg ACA UCAACG GUCGGUG GUuu u
||||||||||||| ||| |||||| ||||||| |||| u
uuccugggguuCC UGU AGUUGC CAGUCAC CAaa u
------------------------a A C -- - aaag
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Landgraf et al. and Lui et al. later verify expression in human [4-5].
Genome context
chr9: 124692442-124692551 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-181a-2
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-181a-2 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-181a-5p
| Accession | MIMAT0000256 |
| Description | Homo sapiens hsa-miR-181a-5p mature miRNA |
| Sequence | 39 - AACAUUCAACGCUGUCGGUGAGU - 61 |
| Evidence |
experimental
cloned [2,4-6] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-181a-2-3p
| Accession | MIMAT0004558 |
| Description | Homo sapiens hsa-miR-181a-2-3p mature miRNA |
| Sequence | 77 - ACCACUGACCGUUGACUGUACC - 98 |
| Evidence |
experimental
cloned [4] |
| Database links |
|
| Predicted targets |
|
References
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