miRBase entry: hsa-mir-181b-1

Stem-loop hsa-mir-181b-1

Homo sapiens hsa-mir-181b-1 precursor miRNA
Gene family
MIPF0000007; mir-181

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR181B1 is a member of the miR181ab1 cluster, which is a key regulator of KRAS-driven carcinogenesis in lung cancer (LC) and pancreatic ductal adenocarcinoma (PDAC) [PMC8430834]. It has been found that certain miRNAs, including MIR181B1, are induced or suppressed upon differentiation [PMC4168020]. MIR181B1 has been implicated in the onset of manic symptoms in bipolar disorder (BD) and has been found to be downregulated in schizophrenia patients with antipsychotic medication [PMC6504680]. On the other hand, MIR181B1 is upregulated in the manic state and shows higher expression in treatment-resistant schizophrenia patients [PMC6504680]. In addition, MIR181B1 has been identified as a gene marker of BD manic episodes [PMC9554663]. Studies have shown that MIR181B1 is necessary for proficient induction of tumorigenesis by mutant KRAS and regulates cell cycle progression [PMC7108928]. It has also been found that combined overexpression of miR181a1 and MIR181B1 enhances tumor growth and cell proliferation rate compared to single overexpression or knockout models [PMC7108928]. Furthermore, miR181a1 and MIR181B1 have non-redundant functions but may be needed together to generate a threshold level of miR181 RNA required for the full oncogenic phenotype [PMC7108928].

Literature search
372 open access papers mention hsa-mir-181b-1
(1614 sentences)


452987 reads, 1441 reads per million, 142 experiments

ccugugcagagauuauuuuuuaaaa       aucAA         CUG          gaac   g 
                         ggucaca     CAUUCAUUG   UCGGUGGGUu    ugu u
                         |||||||     |||||||||   ||||||||||    |||  
                         ccggugu     GUAAGUAAC   AGUCACUCga    aca g
-------------------uucgcc       -cAAC         --A          ----   g 

Annotation confidence High
Do you think this miRNA is real?
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Its expression was later verified in human BC-1 cells [3]. There are two predicted hairpin precursor sequences in the human genome; mir-181b-1 (MIR:MI0000270) is found on chromosome 1 [1], and mir-181b-2 (MIR:MI0000683) on chromosome 9 [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].

Genome context
chr1: 198858873-198858982 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-181b-1
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-181b-1 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-181b-5p

Accession MIMAT0000257
Description Homo sapiens hsa-miR-181b-5p mature miRNA
Evidence experimental
cloned [3-5]
Database links
Predicted targets

Mature hsa-miR-181b-3p

Accession MIMAT0022692
Description Homo sapiens hsa-miR-181b-3p mature miRNA
Evidence not_experimental
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540

  4. PubMed ID: 15634332
    New human and mouse microRNA genes found by homology search
    "Weber MJ"
    "FEBS J (2005) 272:59-73

  5. PubMed ID: 15800047
    Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells
    "Cai X, Lu S, Zhang Z, Gonzalez CM, Damania B, Cullen BR"
    "Proc Natl Acad Sci U S A (2005) 102:5570-5575