Accession
MI0000270
Symbol
HGNC:
MIR181B1
Description
Homo sapiens
hsa-mir-181b-1 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR181B1 is a member of the miR181ab1 cluster, which is a key regulator of KRAS-driven carcinogenesis in lung cancer (LC) and pancreatic ductal adenocarcinoma (PDAC) [PMC8430834]. It has been found that certain miRNAs, including MIR181B1, are induced or suppressed upon differentiation [PMC4168020]. MIR181B1 has been implicated in the onset of manic symptoms in bipolar disorder (BD) and has been found to be downregulated in schizophrenia patients with antipsychotic medication [PMC6504680]. On the other hand, MIR181B1 is upregulated in the manic state and shows higher expression in treatment-resistant schizophrenia patients [PMC6504680]. In addition, MIR181B1 has been identified as a gene marker of BD manic episodes [PMC9554663]. Studies have shown that MIR181B1 is necessary for proficient induction of tumorigenesis by mutant KRAS and regulates cell cycle progression [PMC7108928]. It has also been found that combined overexpression of miR181a1 and MIR181B1 enhances tumor growth and cell proliferation rate compared to single overexpression or knockout models [PMC7108928]. Furthermore, miR181a1 and MIR181B1 have non-redundant functions but may be needed together to generate a threshold level of miR181 RNA required for the full oncogenic phenotype [PMC7108928].
Literature search
372 open access papers mention hsa-mir-181b-1
(1614 sentences)
(1614 sentences)
Sequence
452987
reads,
1441
reads per million, 142 experiments
ccugugcagagauuauuuuuuaaaaggucacaaucAACAUUCAUUGCUGUCGGUGGGUugaacuguguggacaagCUCACUGAACAAUGAAUGCAAcuguggccccgcuu
.........................(((((((.....(((((((((...((((((((((....(((....))))))))))))).)))))))))....)))))))......
.........................(((((((.....(((((((((...((((((((((....(((....))))))))))))).)))))))))....)))))))......
Structure
ccugugcagagauuauuuuuuaaaa aucAA CUG gaac g
ggucaca CAUUCAUUG UCGGUGGGUu ugu u
||||||| ||||||||| |||||||||| |||
ccggugu GUAAGUAAC AGUCACUCga aca g
-------------------uucgcc -cAAC --A ---- g
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Its expression was later verified in human BC-1 cells [3]. There are two predicted hairpin precursor sequences in the human genome; mir-181b-1 (MIR:MI0000270) is found on chromosome 1 [1], and mir-181b-2 (MIR:MI0000683) on chromosome 9 [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].
Genome context
chr1: 198858873-198858982 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-181b-1
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-181b-1 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-181b-5p
| Accession | MIMAT0000257 |
| Description | Homo sapiens hsa-miR-181b-5p mature miRNA |
| Sequence | 36 - AACAUUCAUUGCUGUCGGUGGGU - 58 |
| Evidence |
experimental
cloned [3-5] |
| Database links |
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| Predicted targets |
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Mature hsa-miR-181b-3p
| Accession | MIMAT0022692 |
| Description | Homo sapiens hsa-miR-181b-3p mature miRNA |
| Sequence | 76 - CUCACUGAACAAUGAAUGCAA - 96 |
| Evidence | not_experimental |
| Database links |
|
| Predicted targets |
|
References
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