Accession
MI0000270
Symbol
HGNC:
MIR181B1
Description
Homo sapiens
hsa-mir-181b-1 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR181B1 is a microRNA implicated in various biological processes and diseases, including carcinogenesis and psychiatric disorders [PMC8430834]. It is a critical regulator in KRAS-driven carcinogenesis, particularly in lung cancer (LC) and pancreatic ductal adenocarcinoma (PDAC) [PMC8430834]. MIR181B1 expression is modulated during differentiation, with its suppression observed upon differentiation [PMC4168020]. It has been associated with the onset of manic symptoms in bipolar disorder (BD) and is differentially expressed in schizophrenia patients on antipsychotic medication [PMC6504680]. MIR181B1 expression increases during manic episodes of BD and shows higher expression levels in treatment-resistant schizophrenia patients compared to responsive patients [PMC6504680], [PMC9554663]. However, the statement that MIR181B1 gene expression alterations are linked to regions frequently altered in cancer should be revised, as the reference does not explicitly support this claim for MIR181B1 specifically [PMC7675850], [PMC2683874]. Lastly, the Mir181ab1 cluster, which includes MIR181B1, is necessary for the induction of tumorigenesis by mutant KRAS by regulating cell cycle progression, suggesting a nonredundant function for MIR181B1 alongside miR181a1 in promoting an oncogenic phenotype [PMC7108928].
Literature search
372 open access papers mention hsa-mir-181b-1
(1614 sentences)
(1614 sentences)
Sequence
452987
reads,
784
reads per million, 142 experiments
ccugugcagagauuauuuuuuaaaaggucacaaucAACAUUCAUUGCUGUCGGUGGGUugaacuguguggacaagCUCACUGAACAAUGAAUGCAAcuguggccccgcuu
.........................(((((((.....(((((((((...((((((((((....(((....))))))))))))).)))))))))....)))))))......
.........................(((((((.....(((((((((...((((((((((....(((....))))))))))))).)))))))))....)))))))......
Structure
ccugugcagagauuauuuuuuaaaa aucAA CUG gaac g
ggucaca CAUUCAUUG UCGGUGGGUu ugu u
||||||| ||||||||| |||||||||| |||
ccggugu GUAAGUAAC AGUCACUCga aca g
-------------------uucgcc -cAAC --A ---- g
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Its expression was later verified in human BC-1 cells [3]. There are two predicted hairpin precursor sequences in the human genome; mir-181b-1 (MIR:MI0000270) is found on chromosome 1 [1], and mir-181b-2 (MIR:MI0000683) on chromosome 9 [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].
Genome context
chr1: 198858873-198858982 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-181b-1
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-181b-1 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-181b-5p
| Accession | MIMAT0000257 |
| Description | Homo sapiens hsa-miR-181b-5p mature miRNA |
| Sequence | 36 - AACAUUCAUUGCUGUCGGUGGGU - 58 |
| Evidence |
experimental
cloned [3-5] |
| Database links |
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| Predicted targets |
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Mature hsa-miR-181b-3p
| Accession | MIMAT0022692 |
| Description | Homo sapiens hsa-miR-181b-3p mature miRNA |
| Sequence | 76 - CUCACUGAACAAUGAAUGCAA - 96 |
| Evidence | not_experimental |
| Database links |
|
| Predicted targets |
|
References
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