Accession
MI0000272
Symbol
HGNC:
MIR182
Description
Homo sapiens
hsa-mir-182 precursor miRNA mir-182
Gene
family?
family?
RF00702;
mir-182
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR182 is a microRNA that has been implicated in various types of cancer. It is frequently upregulated in human breast tumor tissues, cell lines, and serum of breast cancer patients compared to healthy controls [PMC5308578]. Similarly, upregulated expression of MIR182 has been observed in lung cancer cells and tissues [PMC5308578]. MIR182 has also been found to be upregulated in clinical tissue samples of melanoma, glioma tumors, ovarian cancer, colorectal cancer, and prostate cancer [PMC5308578]. In these cancers, MIR182 promotes survival, migration, invasion, and metastasis of tumor cells [PMC5308578'>PMC5308578'>PMC5308578'>PMC5308578]. The deregulation of MIR182 in human cancers can be attributed to several possible causes [PMC5308578]. In the context of oral squamous cell carcinoma (OSCC), overexpression of MIR182 has been shown to inhibit apoptosis of OSCC cells [PMC5308578]. Conversely, inhibition of MIR182 enhances apoptosis in OSCC cells [PMC5308578]. The mechanism by which MIR182 functions as an oncogene in OSCC involves the regulation of RASA1 and SPRED1 and leads to constitutive Ras activation [PMC5308578]. Overall, the evidence suggests that MIR182 plays a significant role as an oncogene in various types of cancers by promoting tumor cell survival and metastasis. It is frequently upregulated in different types of tumors and can inhibit apoptosis. The deregulation of MIR182 can be attributed to various causes. In OSCC specifically, it regulates RASA1 and SPRED1 leading to constitutive Ras activation.
Literature search
290 open access papers mention hsa-mir-182
(2366 sentences)
(2366 sentences)
Sequence
86555
reads,
521
reads per million, 146 experiments
gagcugcuugccuccccccguuUUUGGCAAUGGUAGAACUCACACUggugagguaacaggauccggUGGUUCUAGACUUGCCAACUAuggggcgaggacucagccggcac
..((((((.(((((.((((((..(((((((...((((((...((((((..............))))))))))))...)))))))..)))))).)))).)..)).))))..
..((((((.(((((.((((((..(((((((...((((((...((((((..............))))))))))))...)))))))..)))))).)))).)..)).))))..
Structure
ga - -u - c uU UGG UCA ugaggu gcug cu g ccuc ccccgu UUGGCAA UAGAAC CACUgg a |||| || | |||| |||||| ||||||| |||||| |||||| cggc ga c ggag gggguA AACCGUU AUCUUG GUggcc a ca c cu a c UC CAG --- uaggac
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr7: 129770383-129770492 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-182
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-182 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-182-5p
| Accession | MIMAT0000259 |
| Description | Homo sapiens hsa-miR-182-5p mature miRNA |
| Sequence | 23 - UUUGGCAAUGGUAGAACUCACACU - 46 |
| Evidence |
experimental
cloned [2-3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-182-3p
| Accession | MIMAT0000260 |
| Description | Homo sapiens hsa-miR-182-3p mature miRNA |
| Sequence | 67 - UGGUUCUAGACUUGCCAACUA - 87 |
| Evidence | not_experimental |
References
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