miRBase entry: hsa-mir-182

Stem-loop hsa-mir-182

Homo sapiens hsa-mir-182 precursor miRNA
Gene family
MIPF0000116; mir-182

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR182 is a microRNA that has been implicated in various types of cancer. It is frequently upregulated in human breast tumor tissues, cell lines, and serum of breast cancer patients compared to healthy controls [PMC5308578]. Similarly, upregulated expression of MIR182 has been observed in lung cancer cells and tissues [PMC5308578]. MIR182 has also been found to be upregulated in clinical tissue samples of melanoma, glioma tumors, ovarian cancer, colorectal cancer, and prostate cancer [PMC5308578]. In these cancers, MIR182 promotes survival, migration, invasion, and metastasis of tumor cells [PMC5308578'>PMC5308578'>PMC5308578'>PMC5308578]. The deregulation of MIR182 in human cancers can be attributed to several possible causes [PMC5308578].

In the context of oral squamous cell carcinoma (OSCC), overexpression of MIR182 has been shown to inhibit apoptosis of OSCC cells [PMC5308578]. Conversely, inhibition of MIR182 enhances apoptosis in OSCC cells [PMC5308578]. The mechanism by which MIR182 functions as an oncogene in OSCC involves the regulation of RASA1 and SPRED1 and leads to constitutive Ras activation [PMC5308578].

Overall, the evidence suggests that MIR182 plays a significant role as an oncogene in various types of cancers by promoting tumor cell survival and metastasis. It is frequently upregulated in different types of tumors and can inhibit apoptosis. The deregulation of MIR182 can be attributed to various causes. In OSCC specifically, it regulates RASA1 and SPRED1 leading to constitutive Ras activation.

Literature search
290 open access papers mention hsa-mir-182
(2366 sentences)


86555 reads, 521 reads per million, 146 experiments

ga    -  -u -    c      uU       UGG      UCA      ugaggu 
  gcug cu  g ccuc ccccgu  UUGGCAA   UAGAAC   CACUgg      a
  |||| ||  | |||| ||||||  |||||||   ||||||   ||||||       
  cggc ga  c ggag gggguA  AACCGUU   AUCUUG   GUggcc      a
ca    c  cu a    c      UC       CAG      ---      uaggac 

Annotation confidence High
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Genome context
chr7: 129770383-129770492 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-182
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-182 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-182-5p

Accession MIMAT0000259
Description Homo sapiens hsa-miR-182-5p mature miRNA
Evidence experimental
cloned [2-3]
Database links
Predicted targets

Mature hsa-miR-182-3p

Accession MIMAT0000260
Description Homo sapiens hsa-miR-182-3p mature miRNA
Evidence not_experimental


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540