Stem-loop hsa-mir-183

Accession

MI0000273

Symbol

HGNC: MIR183

Description

Homo sapiens hsa-mir-183 precursor miRNA mir-183

Gene
family

RF00663; mir-183

Literature search

202 open access papers mention hsa-mir-183
(1028 sentences)

Sequence

98249 reads, 635 reads per million, 129 experiments

ccgcagagugugacuccuguucugugUAUGGCACUGGUAGAAUUCACUgugaacagucucagucaGUGAAUUACCGAAGGGCCAUAAacagagcagagacagauccacga
.((..((.(.((.(((.((((((((.((((((.((((((..(((((((((((......)))..))))))))))))..)).)))))).))))))))))).)).)))..)).

Structure

c  ca  g g  a   c        g      A  --    GA        --   ac 
 cg  ga u ug cuc uguucugu UAUGGC CU  GGUA  AUUCACUg  uga  a
 ||  || | || ||| |||||||| |||||| ||  ||||  ||||||||  |||   
 gc  cu a ac gag acgagaca AUACCG GA  CCAU  UAAGUGac  acu  g
a  ac  - g  a   -        A      G  AG    --        ug   cu 

Annotation confidence High

Comments

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. Expression was later confirmed in human [2,3]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context

chr7: 129774905-129775014 [-]

Clustered miRNAs

2 other miRNAs are < 10 kb from hsa-mir-183

Disease association

hsa-mir-183 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-183-5p

• Accession: MIMAT0000261
• Description: Homo sapiens hsa-miR-183-5p mature miRNA
• Sequence: 27 - UAUGGCACUGGUAGAAUUCACU - 48
• Evidence: experimental ; cloned [2-4]

Mature hsa-miR-183-3p

• Accession: MIMAT0004560
• Description: Homo sapiens hsa-miR-183-3p mature miRNA
• Sequence: 66 - GUGAAUUACCGAAGGGCCAUAA - 87
• Evidence: experimental ; cloned [3]

References

1. PubMed ID: 12554860
   Numerous microRNPs in neuronal cells containing novel microRNAs
   "Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G"
   "RNA (2003) 9:180-186


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


4. PubMed ID: 12624257
   Vertebrate microRNA genes
   "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
   "Science (2003) 299:1540