miRBase entry: hsa-mir-199b

Stem-loop hsa-mir-199b

Homo sapiens hsa-mir-199b precursor miRNA
Gene family
MIPF0000040; mir-199

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR199B is a type of microRNA that has been studied in various contexts. Over-expression of MIR199B did not significantly affect the levels of HIF-1α mRNA and NFκB mRNA and protein [PMC3645752]. The PCR primers for mature MIR199B were designed and the product length was determined to be 66 bp [PMC3645752]. The deficiency of MIR199B led to the elimination of the protective function of mmu-miR-199b-3p, resulting in increased levels of ACR, BUN, Cr, and proteinuria [PMC8257373]. Interestingly, higher levels of MIR199B were found in the plasma of patients infected with SARS-CoV2 virus [PMC9677482]. In breast cancer, MIR199B was found to be up-regulated along with miR26b, while miR126, miR146a, miR34a were down-regulated [PMC3828615]. The potential role of MIR199B in VEGF transcriptional activation and secretion has been investigated through additional experiments [PMC4737258]. In cancer stem cells and medulloblastoma growth inhibition experiments, inhibition of transcription factor HES1 by MIR199B repressed pluripotency [PMC3645752]. Overexpression of certain microRNAs including MIR199B was associated with shorter survival PFS in certain patients while increased expression of other microRNAs was observed only in patients with intermediate and high cytogenetic risk [PMC6183594].

Literature search
143 open access papers mention hsa-mir-199b
(531 sentences)


3258077 reads, 9807 reads per million, 155 experiments

  a    -acacc    -   c     C       U       U    U   gacu 
cc gagg      ucca cuc gucua CCAGUGU UAGACUA CUGU Cag    c
|| ||||      |||| ||| ||||| ||||||| ||||||| |||| |||     
gg cucc      gggu ggg cggAU GGUUACA GUCUGAU GACA guu    c
  -    cagauu    c   u     U       C       -    u   aaac 

Annotation confidence High
Do you think this miRNA is real?
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised 5' miR has been validated in zebrafish, the ends mapped by cloning [2], and later verified in human [3].

Genome context
chr9: 128244721-128244830 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-199b
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-199b is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-199b-5p

Accession MIMAT0000263
Description Homo sapiens hsa-miR-199b-5p mature miRNA
Evidence experimental
cloned [2-3]
Database links
Predicted targets

Mature hsa-miR-199b-3p

Accession MIMAT0004563
Description Homo sapiens hsa-miR-199b-3p mature miRNA
Evidence experimental
cloned [3]
Database links
Predicted targets


  1. PubMed ID: 14573789
    Reduced accumulation of specific microRNAs in colorectal neoplasia
    "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
    "Mol Cancer Res (2003) 1:882-891

  2. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  3. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540