Accession
MI0000282
Symbol
HGNC:
MIR199B
Description
Homo sapiens
hsa-mir-199b precursor miRNA mir-199
Gene
family?
family?
RF00144;
mir-199
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR199B is a type of microRNA that has been studied in various contexts. Over-expression of MIR199B did not significantly affect the levels of HIF-1α mRNA and NFκB mRNA and protein [PMC3645752]. The PCR primers for mature MIR199B were designed and the product length was determined to be 66 bp [PMC3645752]. The deficiency of MIR199B led to the elimination of the protective function of mmu-miR-199b-3p, resulting in increased levels of ACR, BUN, Cr, and proteinuria [PMC8257373]. Interestingly, higher levels of MIR199B were found in the plasma of patients infected with SARS-CoV2 virus [PMC9677482]. In breast cancer, MIR199B was found to be up-regulated along with miR26b, while miR126, miR146a, miR34a were down-regulated [PMC3828615]. The potential role of MIR199B in VEGF transcriptional activation and secretion has been investigated through additional experiments [PMC4737258]. In cancer stem cells and medulloblastoma growth inhibition experiments, inhibition of transcription factor HES1 by MIR199B repressed pluripotency [PMC3645752]. Overexpression of certain microRNAs including MIR199B was associated with shorter survival PFS in certain patients while increased expression of other microRNAs was observed only in patients with intermediate and high cytogenetic risk [PMC6183594].
Literature search
143 open access papers mention hsa-mir-199b
(531 sentences)
(531 sentences)
Sequence
3258077
reads,
9807
reads per million, 155 experiments
ccagaggacaccuccacuccgucuaCCCAGUGUUUAGACUAUCUGUUCaggacucccaaauuguACAGUAGUCUGCACAUUGGUUAggcugggcuggguuagacccucgg
((.((((.....(((((((.(((((.(((((((.(((((((.((((.(((..........))).))))))))))).))))))).))))).))).))))......))))))
((.((((.....(((((((.(((((.(((((((.(((((((.((((.(((..........))).))))))))))).))))))).))))).))).))))......))))))
Structure
a -acacc - c C U U U gacu cc gagg ucca cuc gucua CCAGUGU UAGACUA CUGU Cag c || |||| |||| ||| ||||| ||||||| ||||||| |||| ||| gg cucc gggu ggg cggAU GGUUACA GUCUGAU GACA guu c - cagauu c u U C - u aaac
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised 5' miR has been validated in zebrafish, the ends mapped by cloning [2], and later verified in human [3].
Genome context
chr9: 128244721-128244830 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-199b
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-199b is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-199b-5p
| Accession | MIMAT0000263 |
| Description | Homo sapiens hsa-miR-199b-5p mature miRNA |
| Sequence | 26 - CCCAGUGUUUAGACUAUCUGUUC - 48 |
| Evidence |
experimental
cloned [2-3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-199b-3p
| Accession | MIMAT0004563 |
| Description | Homo sapiens hsa-miR-199b-3p mature miRNA |
| Sequence | 65 - ACAGUAGUCUGCACAUUGGUUA - 86 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
References
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