Accession
MI0000285
Symbol
HGNC:
MIR205
Description
Homo sapiens
hsa-mir-205 precursor miRNA mir-205
Gene
family?
family?
RF00656;
mir-205
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR205, a type of microRNA, has been found to reduce the expression of various markers associated with the epithelial-mesenchymal process, including CD44, TAZ, E2A.E12, Twist, Snail-1, and mesenchymal CK5 [PMC5705145]. One of the target genes of MIR205 is PRKCE [PMC4052696]. Additionally, MIR205 has been identified alongside other microRNAs such as miR488*, miR125, mir185, miR1 and miR31 [PMC4742123]. Furthermore, a study found that MIR205 is among a group of microRNAs that can predict the presence of a tumor with an AUC value of 0.85 [PMC4815774].
Literature search
320 open access papers mention hsa-mir-205
(1811 sentences)
(1811 sentences)
Sequence
643439
reads,
7630
reads per million, 135 experiments
aaagauccucagacaauccaugugcuucucuugUCCUUCAUUCCACCGGAGUCUGucucauacccaaccaGAUUUCAGUGGAGUGAAGUUCaggaggcauggagcugaca
........((((.(..(((((((....((((((..(((((((((((.((((((((.............)))))))).)))))))))))..))))))))))))))))))..
........((((.(..(((((((....((((((..(((((((((((.((((((((.............)))))))).)))))))))))..))))))))))))))))))..
Structure
aaagaucc a aa gcuu UC C ucuca
ucag c uccaugu cucuug CUUCAUUCCAC GGAGUCUG u
|||| | ||||||| |||||| ||||||||||| |||||||| a
aguc g agguacg gaggaC GAAGUGAGGUG CUUUAGac c
------ac - -- ---- UU A caacc
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Landgraf et al. confirm expression in human [2].
Genome context
chr1: 209432133-209432242 [+]
Disease association
hsa-mir-205 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-205 is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-205 is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-205-5p
| Accession | MIMAT0000266 |
| Description | Homo sapiens hsa-miR-205-5p mature miRNA |
| Sequence | 34 - UCCUUCAUUCCACCGGAGUCUG - 55 |
| Evidence |
experimental
cloned [2-3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-205-3p
| Accession | MIMAT0009197 |
| Description | Homo sapiens hsa-miR-205-3p mature miRNA |
| Sequence | 71 - GAUUUCAGUGGAGUGAAGUUC - 91 |
| Evidence |
experimental
454 [4] |
| Database links |
|
| Predicted targets |
|
References
|
