Stem-loop hsa-mir-205

Accession

MI0000285

Symbol

HGNC: MIR205

Description

Homo sapiens hsa-mir-205 precursor miRNA mir-205

Gene
family

RF00656; mir-205

Literature search

320 open access papers mention hsa-mir-205
(1811 sentences)

Sequence

643439 reads, 7630 reads per million, 135 experiments

aaagauccucagacaauccaugugcuucucuugUCCUUCAUUCCACCGGAGUCUGucucauacccaaccaGAUUUCAGUGGAGUGAAGUUCaggaggcauggagcugaca
........((((.(..(((((((....((((((..(((((((((((.((((((((.............)))))))).)))))))))))..))))))))))))))))))..

Structure

aaagaucc    a aa       gcuu      UC           C        ucuca 
        ucag c  uccaugu    cucuug  CUUCAUUCCAC GGAGUCUG     u
        |||| |  |||||||    ||||||  ||||||||||| ||||||||     a
        aguc g  agguacg    gaggaC  GAAGUGAGGUG CUUUAGac     c
------ac    - --       ----      UU           A        caacc 

Annotation confidence High

Comments

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Landgraf et al. confirm expression in human [2].

Genome context

chr1: 209432133-209432242 [+]

Disease association

hsa-mir-205 is associated with one or more human diseases in the Human microRNA Disease Database

Biological pathways

hsa-mir-205 is involved in one or more biological pathways:

(Source: Reactome)

Biological reactions

hsa-mir-205 is involved in one or more regulation/signalling events:

(Source: Reactome)

Mature hsa-miR-205-5p

• Accession: MIMAT0000266
• Description: Homo sapiens hsa-miR-205-5p mature miRNA
• Sequence: 34 - UCCUUCAUUCCACCGGAGUCUG - 55
• Evidence: experimental ; cloned [2-3]

Mature hsa-miR-205-3p

• Accession: MIMAT0009197
• Description: Homo sapiens hsa-miR-205-3p mature miRNA
• Sequence: 71 - GAUUUCAGUGGAGUGAAGUUC - 91
• Evidence: experimental ; 454 [4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 12624257
   Vertebrate microRNA genes
   "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
   "Science (2003) 299:1540


4. PubMed ID: 19144710
   Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomas
   "Zhu JY, Pfuhl T, Motsch N, Barth S, Nicholls J, Grasser F, Meister G"
   "J Virol (2009) 83:3333-3341