miRBase entry: hsa-mir-205

Stem-loop hsa-mir-205

Homo sapiens hsa-mir-205 precursor miRNA
Gene family
MIPF0000058; mir-205

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR205, a type of microRNA, has been found to reduce the expression of various markers associated with the epithelial-mesenchymal process, including CD44, TAZ, E2A.E12, Twist, Snail-1, and mesenchymal CK5 [PMC5705145]. One of the target genes of MIR205 is PRKCE [PMC4052696]. Additionally, MIR205 has been identified alongside other microRNAs such as miR488*, miR125, mir185, miR1 and miR31 [PMC4742123]. Furthermore, a study found that MIR205 is among a group of microRNAs that can predict the presence of a tumor with an AUC value of 0.85 [PMC4815774].

Literature search
320 open access papers mention hsa-mir-205
(1811 sentences)


643439 reads, 7630 reads per million, 135 experiments

aaagaucc    a aa       gcuu      UC           C        ucuca 
        ucag c  uccaugu    cucuug  CUUCAUUCCAC GGAGUCUG     u
        |||| |  |||||||    ||||||  ||||||||||| ||||||||     a
        aguc g  agguacg    gaggaC  GAAGUGAGGUG CUUUAGac     c
------ac    - --       ----      UU           A        caacc 

Annotation confidence High
Do you think this miRNA is real?
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Landgraf et al. confirm expression in human [2].

Genome context
chr1: 209432133-209432242 [+]

Disease association
hsa-mir-205 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-205 is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-205 is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-205-5p

Accession MIMAT0000266
Description Homo sapiens hsa-miR-205-5p mature miRNA
Evidence experimental
cloned [2-3]
Database links
Predicted targets

Mature hsa-miR-205-3p

Accession MIMAT0009197
Description Homo sapiens hsa-miR-205-3p mature miRNA
Evidence experimental
454 [4]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540

  4. PubMed ID: 19144710
    Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomas
    "Zhu JY, Pfuhl T, Motsch N, Barth S, Nicholls J, Grasser F, Meister G"
    "J Virol (2009) 83:3333-3341