Stem-loop hsa-mir-210

Accession

MI0000286

Symbol

HGNC: MIR210

Description

Homo sapiens hsa-mir-210 precursor miRNA

Literature search

334 open access papers mention hsa-mir-210
(2490 sentences)

Sequence

53209 reads, 166 reads per million, 159 experiments

acccggcagugccuccaggcgcagggcAGCCCCUGCCCACCGCACACUGcgcugccccagacccaCUGUGCGUGUGACAGCGGCUGAucugugccugggcagcgcgaccc
....((..((((.(((((((((((..(((((.(((..(((((((((.((.((((...))).).)).)))))).))).))).)))))..)))))))))))..))))..)).

Structure

accc  ca    -c           gg     C   CC   -      C  c -   c 
    gg  gugc  uccaggcgcag  cAGCC CUG  CAC CGCACA UG g cug  
    ||  ||||  |||||||||||  ||||| |||  ||| |||||| || | ||| c
    cc  cgcg  ggguccguguc  GUCGG GAC  GUG GCGUGU ac c gac  
---c  ag    ac           uA     C   -A   U      C  c a   c 

Annotation confidence High

Comments

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Its expression was later verified in human BC-1 cells [2].

Genome context

chr11: 568089-568198 [-]

Disease association

hsa-mir-210 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-210-3p

• Accession: MIMAT0000267
• Description: Homo sapiens hsa-miR-210-3p mature miRNA
• Sequence: 66 - CUGUGCGUGUGACAGCGGCUGA - 87
• Evidence: experimental ; cloned [2-4], Illumina [5]

Mature hsa-miR-210-5p

• Accession: MIMAT0026475
• Description: Homo sapiens hsa-miR-210-5p mature miRNA
• Sequence: 28 - AGCCCCUGCCCACCGCACACUG - 49
• Evidence: experimental ; Illumina [5]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 12624257
   Vertebrate microRNA genes
   "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
   "Science (2003) 299:1540


4. PubMed ID: 15800047
   Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells
   "Cai X, Lu S, Zhang Z, Gonzalez CM, Damania B, Cullen BR"
   "Proc Natl Acad Sci U S A (2005) 102:5570-5575


5. PubMed ID: 23034410
   Birth and expression evolution of mammalian microRNA genes
   "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
   "Genome Res (2013) 23:34-45