miRBase entry: hsa-mir-210

Stem-loop hsa-mir-210

Homo sapiens hsa-mir-210 precursor miRNA
Gene family
MIPF0000086; mir-210

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR210 is a microRNA that is associated with neuroinflammation and hypoxia in Parkinson's disease (PD) [PMC7215947]. In a study, changes in the relative expression levels of three microRNAs, including MIR210, were assessed in a pre-motor PD model [PMC7215947]. A hydrogel loaded with the secretory body from the human ADSC line HATMSC2 was found to have high levels of MIR210, indicating its potential in chronic wound treatment [PMC9742286]. Overexpression of MIR210 was observed in advanced hepatocellular carcinoma (HCC) and was associated with higher disease stage, poor overall and disease-free survival, and high incidence of recurrence after chemotherapy [PMC8799276]. Transgenic mouse experiments using doxycycline-inducible transgenic mice showed the use of MIR210 (Tg-210) [PMC8088433]. HIF-1α was found to be required for the induction of MIR210 in activated T cells, suggesting that HIF-1 acts upstream of miR-210 [PMC3996831]. In addition to MIR210, miR21 and miR155 were also studied for their cancer and immune-related functions [PMC6862702].

MIR210 is a hypoxia-associated microRNA that has been implicated in neuroinflammation and various diseases such as Parkinson's disease (PD) and hepatocellular carcinoma (HCC) [PMC7215947] [PMC9742286] [PMC8799276] [PMC8088433] [PMC3996831]  [PMC6862702].

Literature search
334 open access papers mention hsa-mir-210
(2490 sentences)


53214 reads, 423 reads per million, 159 experiments

accc  ca    -c           gg     C   CC   -      C  c -   c 
    gg  gugc  uccaggcgcag  cAGCC CUG  CAC CGCACA UG g cug  
    ||  ||||  |||||||||||  ||||| |||  ||| |||||| || | ||| c
    cc  cgcg  ggguccguguc  GUCGG GAC  GUG GCGUGU ac c gac  
---c  ag    ac           uA     C   -A   U      C  c a   c 

Annotation confidence High
Do you think this miRNA is real?
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Its expression was later verified in human BC-1 cells [2].

Genome context
chr11: 568089-568198 [-]

Disease association
hsa-mir-210 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-210-3p

Accession MIMAT0000267
Description Homo sapiens hsa-miR-210-3p mature miRNA
Evidence experimental
cloned [2-4], Illumina [5]
Database links
Predicted targets

Mature hsa-miR-210-5p

Accession MIMAT0026475
Description Homo sapiens hsa-miR-210-5p mature miRNA
Evidence experimental
Illumina [5]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540

  4. PubMed ID: 15800047
    Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells
    "Cai X, Lu S, Zhang Z, Gonzalez CM, Damania B, Cullen BR"
    "Proc Natl Acad Sci U S A (2005) 102:5570-5575

  5. PubMed ID: 23034410
    Birth and expression evolution of mammalian microRNA genes
    "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
    "Genome Res (2013) 23:34-45