Accession
MI0000288
Symbol
HGNC:
MIR212
Description
Homo sapiens
hsa-mir-212 precursor miRNA mir-132
Gene
family?
family?
RF00662;
mir-132
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR212 is a microRNA that has been implicated in the regulation of cellular processes in ovarian cancer (OC) cell lines, including proliferation and apoptosis [PMC6995389]. In a meta-analysis, MIR212 was identified among eight microRNAs that showed a significant association with CAG length, suggesting its potential involvement in genetic regulation related to this trinucleotide repeat [PMC5764268]. The findings from the meta-analysis were further supported by data from human brain tissue (BA9), reinforcing the relevance of MIR212 in genetic studies [PMC5764268]. The research on MIR212 contributes to our understanding of its role in OC and possibly other cellular or genetic contexts.
Literature search
129 open access papers mention hsa-mir-212
(875 sentences)
(875 sentences)
Sequence
8023
reads,
228
reads per million, 89 experiments
cggggcaccccgcccggacagcgcgccggcACCUUGGCUCUAGACUGCUUACUgcccgggccgcccucagUAACAGUCUCCAGUCACGGCCaccgacgccuggccccgcc
((((((...((....)).(((.(((.(((..((.(((((..((((((.((((((...(((...))).))))))))))))..))))).))...))).))))))))))))..
((((((...((....)).(((.(((.(((..((.(((((..((((((.((((((...(((...))).))))))))))))..))))).))...))).))))))))))))..
Structure
-- accccgcccgga c c -cA U CU C ccc c cggggc cag gcg cgg CC UGGCU AGACUG UUACUg ggg |||||| ||| ||| ||| || ||||| |||||| |||||| ||| c gccccg guc cgc gcc GG ACUGA UCUGAC AAUgac ccc cc ------------ - a aCC C CC - --u g
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. The 3' end was not experimentally determined. The sequence maps to human chromosome 17, but its expression has not been experimentally verified in human.
Genome context
chr17: 2050271-2050380 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-212
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-212 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-212-3p
| Accession | MIMAT0000269 |
| Description | Homo sapiens hsa-miR-212-3p mature miRNA |
| Sequence | 71 - UAACAGUCUCCAGUCACGGCC - 91 |
| Evidence | not_experimental |
| Database links |
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| Predicted targets |
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Mature hsa-miR-212-5p
| Accession | MIMAT0022695 |
| Description | Homo sapiens hsa-miR-212-5p mature miRNA |
| Sequence | 31 - ACCUUGGCUCUAGACUGCUUACU - 53 |
| Evidence | not_experimental |
| Database links |
|
| Predicted targets |
|
References
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