Stem-loop hsa-mir-212

Accession

MI0000288

Symbol

HGNC: MIR212

Description

Homo sapiens hsa-mir-212 precursor miRNA mir-132

Gene
family

RF00662; mir-132

Literature search

129 open access papers mention hsa-mir-212
(875 sentences)

Sequence

8015 reads, 86 reads per million, 89 experiments

cggggcaccccgcccggacagcgcgccggcACCUUGGCUCUAGACUGCUUACUgcccgggccgcccucagUAACAGUCUCCAGUCACGGCCaccgacgccuggccccgcc
((((((...((....)).(((.(((.(((..((.(((((..((((((.((((((...(((...))).))))))))))))..))))).))...))).))))))))))))..

Structure

--      accccgcccgga   c   c   -cA  U     CU      C      ccc   c 
  cggggc            cag gcg cgg   CC UGGCU  AGACUG UUACUg   ggg  
  ||||||            ||| ||| |||   || |||||  |||||| ||||||   ||| c
  gccccg            guc cgc gcc   GG ACUGA  UCUGAC AAUgac   ccc  
cc      ------------   -   a   aCC  C     CC      -      --u   g 

Annotation confidence High

Comments

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. The 3' end was not experimentally determined. The sequence maps to human chromosome 17, but its expression has not been experimentally verified in human.

Genome context

chr17: 2050271-2050380 [-]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-212

Disease association

hsa-mir-212 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-212-3p

• Accession: MIMAT0000269
• Description: Homo sapiens hsa-miR-212-3p mature miRNA
• Sequence: 71 - UAACAGUCUCCAGUCACGGCC - 91
• Evidence: not_experimental

Mature hsa-miR-212-5p

• Accession: MIMAT0022695
• Description: Homo sapiens hsa-miR-212-5p mature miRNA
• Sequence: 31 - ACCUUGGCUCUAGACUGCUUACU - 53
• Evidence: not_experimental

References

1. PubMed ID: 12624257
   Vertebrate microRNA genes
   "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
   "Science (2003) 299:1540