Stem-loop hsa-mir-215

Accession

MI0000291

Symbol

HGNC: MIR215

Description

Homo sapiens hsa-mir-215 precursor miRNA mir-192

Gene
family

RF00130; mir-192

Literature search

102 open access papers mention hsa-mir-215
(417 sentences)

Sequence

21961 reads, 75 reads per million, 86 experiments

aucauucagaaaugguauacaggaaaAUGACCUAUGAAUUGACAGACaauauagcugaguuugUCUGUCAUUUCUUUAGGCCAAUAuucuguaugacugugcuacuucaa
...........(((((((((((((...((.((((.(((.((((((((((...........)))))))))).)))..)))).))...)))))))).)))))..........

Structure

aucauucagaa     -        aaA  A    -U   U          uaua 
           auggu auacagga   UG CCUA  GAA UGACAGACaa    g
           ||||| ||||||||   || ||||  ||| ||||||||||    c
           uguca uaugucuu   AC GGAU  CUU ACUGUCUguu    u
-aacuucaucg     g        AUA  C    UU   U          ugag 

Annotation confidence Not enough data

Comments

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. Landgraf et al. confirm expression in human [2].

Genome context

chr1: 220117853-220117962 [-]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-215

Disease association

hsa-mir-215 is associated with one or more human diseases in the Human microRNA Disease Database

Biological pathways

hsa-mir-215 is involved in one or more biological pathways:

(Source: Reactome)

Biological reactions

hsa-mir-215 is involved in one or more regulation/signalling events:

(Source: Reactome)

Mature hsa-miR-215-5p

• Accession: MIMAT0000272
• Description: Homo sapiens hsa-miR-215-5p mature miRNA
• Sequence: 27 - AUGACCUAUGAAUUGACAGAC - 47
• Evidence: experimental ; cloned [2], Illumina [3]

Mature hsa-miR-215-3p

• Accession: MIMAT0026476
• Description: Homo sapiens hsa-miR-215-3p mature miRNA
• Sequence: 64 - UCUGUCAUUUCUUUAGGCCAAUA - 86
• Evidence: experimental ; Illumina [3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12624257
   Vertebrate microRNA genes
   "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
   "Science (2003) 299:1540


3. PubMed ID: 23034410
   Birth and expression evolution of mammalian microRNA genes
   "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
   "Genome Res (2013) 23:34-45