Accession
MI0000293
Symbol
HGNC:
MIR217
Description
Homo sapiens
hsa-mir-217 precursor miRNA mir-217
Gene
family?
family?
RF00673;
mir-217
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR217 is a type of microRNA that has been studied in various tumor types, including KIRP [PMC7744790]. In type 2 KIRP, the expression of IGF2BP3, NCAPG, and MIR217 was found to be higher compared to type 1 KIRP [PMC7744790]. In a study using 6DT1 cells, the expression of Mir216b and MIR217 resulted in a significant suppression of pulmonary metastasis [PMC3912413]. MIR217, along with miR-34a, has been shown to downregulate the mRNA and protein levels of silent information regulator 1 (SIRT1), leading to weakened antioxidant capacity and vascular endothelial aging [PMC9513221]. The relationship between LINC01268, MIR217, and SOS1 was explored in AML cells (HL-60 and Kasumi-1), where their effects on cell viability, cycle progression, and apoptosis were determined [PMC7326380]. Additionally, MIR217 has been found to interact with several splicing factors and bind to miRNAs such as miR-101, miR-9, miR-125b [PMC6351443]. The expression level of MIR217 was downregulated in TNBS-induced inflammation but significantly upregulated by BEY-treatment [PMC9101272].
Literature search
100 open access papers mention hsa-mir-217
(638 sentences)
(638 sentences)
Sequence
8853
reads,
248
reads per million, 44 experiments
aguauaauuauuacauaguuuuugaugucgcagaUACUGCAUCAGGAACUGAUUGGAuaagaaucagucacCAUCAGUUCCUAAUGCAUUGCCuucagcaucuaaacaag
.(((.......)))...((((..(((((.(.((.((.(((((.((((((((((.((((........))).).)))))))))).))))).)).)).).))))).))))...
.(((.......)))...((((..(((((.(.((.((.(((((.((((((((((.((((........))).).)))))))))).))))).)).)).).))))).))))...
Structure
aguauaauuauuacaua uu c c a C C U - aag
guuu gaugu g ag UA UGCAU AGGAACUGAU G GAu a
|||| ||||| | || || ||||| |||||||||| | |||
caaa cuacg c uC GU ACGUA UCCUUGACUA c cug a
--------------gaa -u a u C U A C a acu
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr2: 55982967-55983076 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-217
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-217 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-217-5p
| Accession | MIMAT0000274 |
| Description | Homo sapiens hsa-miR-217-5p mature miRNA |
| Sequence | 35 - UACUGCAUCAGGAACUGAUUGGA - 57 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-217-3p
| Accession | MIMAT0037308 |
| Description | Homo sapiens hsa-miR-217-3p mature miRNA |
| Sequence | 72 - CAUCAGUUCCUAAUGCAUUGCC - 93 |
| Evidence | not_experimental |
References
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