Stem-loop hsa-mir-218-1

Accession

MI0000294

Symbol

HGNC: MIR218-1

Description

Homo sapiens hsa-mir-218-1 precursor miRNA mir-218

Gene
family

RF00255; mir-218

Literature search

177 open access papers mention hsa-mir-218-1
(1072 sentences)

Sequence

207527 reads, 775 reads per million, 133 experiments

gugauaauguagcgagauuuucugUUGUGCUUGAUCUAACCAUGUgguugcgagguaugaguaaaacAUGGUUCCGUCAAGCACCAUGGaacgucacgcagcuuucuaca
(((..((.((.(((.(((.((((((.(((((((((..((((((((..((((.........)))).))))))))..))))))))).)))))).))).))).))))..))).

Structure

-   au  u  a   a   u      U         CU        gg    gag 
 gug  aa gu gcg gau uucugU GUGCUUGAU  AACCAUGU  uugc   g
 |||  || || ||| ||| |||||| |||||||||  ||||||||  ||||   u
 cau  uu cg cgc cug aaGGUA CACGAACUG  UUGGUAca  aaug   a
a   cu  -  a   a   c      C         CC        -a    agu 

Annotation confidence High

Comments

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. Landgraf et al. later verified the expression of miR-218 in human [2].

Genome context

chr4: 20528275-20528384 [+]

Disease association

hsa-mir-218-1 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-218-5p

• Accession: MIMAT0000275
• Description: Homo sapiens hsa-miR-218-5p mature miRNA
• Sequence: 25 - UUGUGCUUGAUCUAACCAUGU - 45
• Evidence: experimental ; cloned [2-3]

Mature hsa-miR-218-1-3p

• Accession: MIMAT0004565
• Description: Homo sapiens hsa-miR-218-1-3p mature miRNA
• Sequence: 68 - AUGGUUCCGUCAAGCACCAUGG - 89
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 12624257
   Vertebrate microRNA genes
   "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
   "Science (2003) 299:1540