miRBase entry: hsa-mir-218-1

Stem-loop hsa-mir-218-1

HGNC: MIR218-1
Homo sapiens hsa-mir-218-1 precursor miRNA
Gene family
MIPF0000026; mir-218

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR218-1 is a microRNA that is involved in various biological processes and has been found to be dysregulated in different diseases, including cancer and valve disease [PMC4748271] [PMC2683874] [PMC7197751]. Overexpression of the Wnt signaling pathway has been shown to increase the levels of MIR218-1, as well as its precursor MIR218-1, in certain cancer types [PMC4748271]. In kidney and prostate cancers, MIR218-1 is one of several dysregulated microRNAs that target the CUL3 gene [PMC2683874]. In valve disease, MIR218-1 is reduced in all grades of the disease, suggesting its potential role in disease progression [PMC7197751]. MIR218-1 is also found within the intron of SLIT2 gene and has been shown to affect tumor angiogenesis and cell migration in various cancers [PMC5909645] [PMC6712160]. Additionally, MIR218-1 is up-regulated in stenotic colon segments compared to normal colon tissue [PMC4774952]. In both human and zebrafish, MIR218-1 and its homolog miR218-2 are independently regulated microRNAs with host genes SLIT2 and SLIT3 respectively[PMC6523689]. Overall, these findings highlight the importance of MIR218-1 in different diseases and its potential as a therapeutic target.

Literature search
177 open access papers mention hsa-mir-218-1
(1072 sentences)


207527 reads, 1697 reads per million, 133 experiments

-   au  u  a   a   u      U         CU        gg    gag 
 gug  aa gu gcg gau uucugU GUGCUUGAU  AACCAUGU  uugc   g
 |||  || || ||| ||| |||||| |||||||||  ||||||||  ||||   u
 cau  uu cg cgc cug aaGGUA CACGAACUG  UUGGUAca  aaug   a
a   cu  -  a   a   c      C         CC        -a    agu 

Annotation confidence High
Do you think this miRNA is real?
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. Landgraf et al. later verified the expression of miR-218 in human [2].

Genome context
chr4: 20528275-20528384 [+]

Disease association
hsa-mir-218-1 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-218-5p

Accession MIMAT0000275
Description Homo sapiens hsa-miR-218-5p mature miRNA
Evidence experimental
cloned [2-3]
Database links
Predicted targets

Mature hsa-miR-218-1-3p

Accession MIMAT0004565
Description Homo sapiens hsa-miR-218-1-3p mature miRNA
Evidence experimental
cloned [2]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540