Accession
MI0000294
Symbol
HGNC:
MIR218-1
Description
Homo sapiens
hsa-mir-218-1 precursor miRNA mir-218
Gene
family?
family?
RF00255;
mir-218
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR218-1 is a microRNA that is involved in various biological processes and has been found to be dysregulated in different diseases, including cancer and valve disease [PMC4748271] [PMC2683874] [PMC7197751]. Overexpression of the Wnt signaling pathway has been shown to increase the levels of MIR218-1, as well as its precursor MIR218-1, in certain cancer types [PMC4748271]. In kidney and prostate cancers, MIR218-1 is one of several dysregulated microRNAs that target the CUL3 gene [PMC2683874]. In valve disease, MIR218-1 is reduced in all grades of the disease, suggesting its potential role in disease progression [PMC7197751]. MIR218-1 is also found within the intron of SLIT2 gene and has been shown to affect tumor angiogenesis and cell migration in various cancers [PMC5909645] [PMC6712160]. Additionally, MIR218-1 is up-regulated in stenotic colon segments compared to normal colon tissue [PMC4774952]. In both human and zebrafish, MIR218-1 and its homolog miR218-2 are independently regulated microRNAs with host genes SLIT2 and SLIT3 respectively[PMC6523689]. Overall, these findings highlight the importance of MIR218-1 in different diseases and its potential as a therapeutic target.
Literature search
177 open access papers mention hsa-mir-218-1
(1072 sentences)
(1072 sentences)
Sequence
207527
reads,
1697
reads per million, 133 experiments
gugauaauguagcgagauuuucugUUGUGCUUGAUCUAACCAUGUgguugcgagguaugaguaaaacAUGGUUCCGUCAAGCACCAUGGaacgucacgcagcuuucuaca
(((..((.((.(((.(((.((((((.(((((((((..((((((((..((((.........)))).))))))))..))))))))).)))))).))).))).))))..))).
(((..((.((.(((.(((.((((((.(((((((((..((((((((..((((.........)))).))))))))..))))))))).)))))).))).))).))))..))).
Structure
- au u a a u U CU gg gag gug aa gu gcg gau uucugU GUGCUUGAU AACCAUGU uugc g ||| || || ||| ||| |||||| ||||||||| |||||||| |||| u cau uu cg cgc cug aaGGUA CACGAACUG UUGGUAca aaug a a cu - a a c C CC -a agu
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. Landgraf et al. later verified the expression of miR-218 in human [2].
Genome context
chr4: 20528275-20528384 [+]
Disease association
hsa-mir-218-1 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-218-5p
| Accession | MIMAT0000275 |
| Description | Homo sapiens hsa-miR-218-5p mature miRNA |
| Sequence | 25 - UUGUGCUUGAUCUAACCAUGU - 45 |
| Evidence |
experimental
cloned [2-3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-218-1-3p
| Accession | MIMAT0004565 |
| Description | Homo sapiens hsa-miR-218-1-3p mature miRNA |
| Sequence | 68 - AUGGUUCCGUCAAGCACCAUGG - 89 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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