Accession
MI0000295
Symbol
HGNC:
MIR218-2
Description
Homo sapiens
hsa-mir-218-2 precursor miRNA mir-218
Gene
family?
family?
RF00255;
mir-218
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR218-2 is a microRNA encoded within an intron of the SLIT3 gene [PMC5909645]. It is involved in neuron differentiation [PMC3020728]. In the cortex of Alzheimer's disease (AD) patients, MIR218-2 is upregulated [PMC7564652]. MIR218-2 has not been previously studied or reported in the brain tissue of AD patients [PMC7564652]. MIR218-2 targets Tau and its phosphorylation, as well as secretases [PMC7564652]. In Parkinson's disease (PD) patients, MIR218-2 is notably down-regulated [PMC5288660]. Overexpression of the Wnt signaling pathway increases the levels of MIR218-2 [PMC4748271]. The variant rs11134527, located outside the MIR218-2 hairpin sequence, significantly changes the expression of miR-218-5p [PMC4439572]. In kidney and prostate cancers, several dysregulated microRNAs including MIR218-1 and MIR218-2 are involved in targeting CUL3 gene expression [PMC2683874]. MIR218-1 is another microRNA encoded within an intron, specifically within the SLIT2 gene [PMC2683874]. It has been found to be downregulated in AD patients' cortex [PMC7564652'>PMC7564652'>PMC7564652]. Other dysregulated microRNAs in AD include MIR129-2, MIR1296, MIR219A1, MIR29B1, MIR375, MIR411, and MIR431 [PMC7564652]. On the other hand, upregulated microRNAs include: 199A2, 24-92A1, and 99A [PMC7564652]. These findings suggest a potential role for these dysregulated microRNAs in AD pathology [PMC7564652].
Literature search
177 open access papers mention hsa-mir-218-2
(1073 sentences)
(1073 sentences)
Sequence
202171
reads,
1561
reads per million, 131 experiments
gaccagucgcugcggggcuuuccuUUGUGCUUGAUCUAACCAUGUgguggaacgauggaaacggaaCAUGGUUCUGUCAAGCACCGCGgaaagcaccgugcucuccugca
...(((..((.((((.(((((((...(((((((((..((((((((..((............))..))))))))..)))))))))...))))))).))))))....)))..
...(((..((.((((.(((((((...(((((((((..((((((((..((............))..))))))))..)))))))))...))))))).))))))....)))..
Structure
gac --uc u g uUU CU gg gaacg cag gc gcgg gcuuucc GUGCUUGAU AACCAUGU ug a ||| || |||| ||||||| ||||||||| |||||||| || guc cg ugcc cgaaagG CACGAACUG UUGGUACa gc u -ac cucu - a CGC UC ag aaagg
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. Landgraf et al. confirm expression in human [2].
Genome context
chr5: 168768146-168768255 [-]
Disease association
hsa-mir-218-2 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-218-5p
| Accession | MIMAT0000275 |
| Description | Homo sapiens hsa-miR-218-5p mature miRNA |
| Sequence | 25 - UUGUGCUUGAUCUAACCAUGU - 45 |
| Evidence |
experimental
cloned [2-3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-218-2-3p
| Accession | MIMAT0004566 |
| Description | Homo sapiens hsa-miR-218-2-3p mature miRNA |
| Sequence | 67 - CAUGGUUCUGUCAAGCACCGCG - 88 |
| Evidence |
experimental
cloned [2] |
References
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