Accession
MI0000295
Symbol
HGNC:
MIR218-2
Description
Homo sapiens
hsa-mir-218-2 precursor miRNA mir-218
Gene
family?
family?
RF00255;
mir-218
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR218-2 is a microRNA encoded within an intron of the SLIT3 gene and is implicated in neuron differentiation [PMC3020728]. This microRNA, along with its counterpart MIR218-1 from the SLIT2 gene, can be independently regulated in both humans and zebrafish [PMC6523689]. In the context of Alzheimer's disease (AD), MIR218-2 is among the microRNAs that are upregulated in the cortex of patients, suggesting a role in disease pathology [PMC7564652]. Notably, MIR218-2 has been identified as targeting Tau protein and its phosphorylation, which are key features of AD [PMC7564652]. In addition to its role in AD, MIR218-2 expression is influenced by genetic variants such as rs11134527 located near its hairpin sequence [PMC4439572]. Furthermore, it has been found to be downregulated in Parkinson's disease (PD) patients [PMC5288660], indicating a broader involvement in neurodegenerative diseases. The expression of MIR218-2 can also be modulated by signaling pathways such as Wnt signaling which has been shown to increase its levels [PMC4748271]. Lastly, it targets CUL3 which is overexpressed in kidney and prostate cancers; thus it may play a role in cancer biology as well [PMC2683874].
Literature search
177 open access papers mention hsa-mir-218-2
(1073 sentences)
(1073 sentences)
Sequence
202171
reads,
1561
reads per million, 131 experiments
gaccagucgcugcggggcuuuccuUUGUGCUUGAUCUAACCAUGUgguggaacgauggaaacggaaCAUGGUUCUGUCAAGCACCGCGgaaagcaccgugcucuccugca
...(((..((.((((.(((((((...(((((((((..((((((((..((............))..))))))))..)))))))))...))))))).))))))....)))..
...(((..((.((((.(((((((...(((((((((..((((((((..((............))..))))))))..)))))))))...))))))).))))))....)))..
Structure
gac --uc u g uUU CU gg gaacg cag gc gcgg gcuuucc GUGCUUGAU AACCAUGU ug a ||| || |||| ||||||| ||||||||| |||||||| || guc cg ugcc cgaaagG CACGAACUG UUGGUACa gc u -ac cucu - a CGC UC ag aaagg
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. Landgraf et al. confirm expression in human [2].
Genome context
chr5: 168768146-168768255 [-]
Disease association
hsa-mir-218-2 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-218-5p
| Accession | MIMAT0000275 |
| Description | Homo sapiens hsa-miR-218-5p mature miRNA |
| Sequence | 25 - UUGUGCUUGAUCUAACCAUGU - 45 |
| Evidence |
experimental
cloned [2-3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-218-2-3p
| Accession | MIMAT0004566 |
| Description | Homo sapiens hsa-miR-218-2-3p mature miRNA |
| Sequence | 67 - CAUGGUUCUGUCAAGCACCGCG - 88 |
| Evidence |
experimental
cloned [2] |
References
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