miRBase entry: hsa-mir-218-2

Stem-loop hsa-mir-218-2

HGNC: MIR218-2
Homo sapiens hsa-mir-218-2 precursor miRNA
Gene family
MIPF0000026; mir-218

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR218-2 is a microRNA encoded within an intron of the SLIT3 gene [PMC5909645]. It is involved in neuron differentiation [PMC3020728]. In the cortex of Alzheimer's disease (AD) patients, MIR218-2 is upregulated [PMC7564652]. MIR218-2 has not been previously studied or reported in the brain tissue of AD patients [PMC7564652]. MIR218-2 targets Tau and its phosphorylation, as well as secretases [PMC7564652]. In Parkinson's disease (PD) patients, MIR218-2 is notably down-regulated [PMC5288660]. Overexpression of the Wnt signaling pathway increases the levels of MIR218-2 [PMC4748271]. The variant rs11134527, located outside the MIR218-2 hairpin sequence, significantly changes the expression of miR-218-5p [PMC4439572]. In kidney and prostate cancers, several dysregulated microRNAs including MIR218-1 and MIR218-2 are involved in targeting CUL3 gene expression [PMC2683874].

MIR218-1 is another microRNA encoded within an intron, specifically within the SLIT2 gene [PMC2683874]. It has been found to be downregulated in AD patients' cortex [PMC7564652'>PMC7564652'>PMC7564652]. Other dysregulated microRNAs in AD include MIR129-2, MIR1296, MIR219A1, MIR29B1, MIR375, MIR411, and MIR431 [PMC7564652]. On the other hand, upregulated microRNAs include: 199A2, 24-92A1, and 99A [PMC7564652]. These findings suggest a potential role for these dysregulated microRNAs in AD pathology [PMC7564652].

Literature search
177 open access papers mention hsa-mir-218-2
(1073 sentences)


202171 reads, 1561 reads per million, 131 experiments

gac   --uc  u    g       uUU         CU        gg  gaacg 
   cag    gc gcgg gcuuucc   GUGCUUGAU  AACCAUGU  ug     a
   |||    || |||| |||||||   |||||||||  ||||||||  ||      
   guc    cg ugcc cgaaagG   CACGAACUG  UUGGUACa  gc     u
-ac   cucu  -    a       CGC         UC        ag  aaagg 

Annotation confidence High
Do you think this miRNA is real?
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. Landgraf et al. confirm expression in human [2].

Genome context
chr5: 168768146-168768255 [-]

Disease association
hsa-mir-218-2 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-218-5p

Accession MIMAT0000275
Description Homo sapiens hsa-miR-218-5p mature miRNA
Evidence experimental
cloned [2-3]
Database links
Predicted targets

Mature hsa-miR-218-2-3p

Accession MIMAT0004566
Description Homo sapiens hsa-miR-218-2-3p mature miRNA
Evidence experimental
cloned [2]


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540