Accession
MI0000296
Symbol
HGNC:
MIR219A1
Description
Homo sapiens
hsa-mir-219a-1 precursor miRNA mir-219
Gene
family?
family?
RF00251;
mir-219
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR219A1 is a microRNA that is downregulated in the brain of Alzheimer's disease (AD) patients [PMC7564652]. In the cortex of AD patients, MIR219A1 is also found to be downregulated [PMC7564652]. MIR219A1, along with other miRNAs such as MIR29B1, MIR129-2, MIR199A2, MIR92A1, and MIR1296, has been observed to be dysregulated in AD patients [PMC7564652]. Specifically, in AD patients, MIR219A1 targets Tau and its phosphorylation [PMC7564652]. In addition to its role in AD pathology, the microRNA gene MIR219A1 has been associated with significant associations with other loci in genome-wide association studies (GWAS) [PMC4895015]. Furthermore, the expression of MIR219A1 has been found to be altered in various contexts such as pre-miRNAs and miRNAs associated with specific pathways [PMC5538553]. Overall, these findings highlight the importance of understanding the role of microRNAs like MIR219A1 in AD pathology and their potential as therapeutic targets.
Literature search
70 open access papers mention hsa-mir-219a-1
(248 sentences)
(248 sentences)
Sequence
1603
reads,
64
reads per million, 91 experiments
ccgccccgggccgcggcuccUGAUUGUCCAAACGCAAUUCUcgagucuauggcuccggccgAGAGUUGAGUCUGGACGUCCCGagccgccgcccccaaaccucgagcggg
((((.(.((((.(((((((..(((.(((((.((.(((((((((.(((.........)))))))))))).)).))))))))..))))))).)))).........).)))).
((((.(.((((.(((((((..(((.(((((.((.(((((((((.(((.........)))))))))))).)).))))))))..))))))).)))).........).)))).
Structure
- c --------c c cU U A G a uau ccgc c gggc gcggcuc GAU GUCCA AC CAAUUCUcg guc g |||| | |||| ||||||| ||| ||||| || ||||||||| ||| g ggcg g cccg cgccgaG CUG CAGGU UG GUUGAGAgc cgg c g a cuccaaacc c CC - C A - ccu
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the 5' excised miR has been validated in zebrafish, and the 5' end mapped by PCR [2]. The mature products were later validated in human [3]. Two hairpin precursor structures are predicted, mir-219-1 on chromosome 6 (MIR:MI0000296) and mir-219-2 on chromosome 9 (MIR:MI0000740) [2].
Genome context
chr6: 33207835-33207944 [+]
Disease association
hsa-mir-219a-1 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-219a-5p
| Accession | MIMAT0000276 |
| Description | Homo sapiens hsa-miR-219a-5p mature miRNA |
| Sequence | 21 - UGAUUGUCCAAACGCAAUUCU - 41 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-219a-1-3p
| Accession | MIMAT0004567 |
| Description | Homo sapiens hsa-miR-219a-1-3p mature miRNA |
| Sequence | 62 - AGAGUUGAGUCUGGACGUCCCG - 83 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
References
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