miRBase entry: hsa-mir-222

Stem-loop hsa-mir-222

Homo sapiens hsa-mir-222 precursor miRNA
Gene family
MIPF0000051; mir-221

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR222 is a microRNA that has been studied in various contexts [PMC8762293]. Lentivirus-mediated transfer of the MIR222 gene has been shown to promote adipogenesis in 3T3-L1 cells, as evidenced by the up-regulation of C/EBPα and PPARγ [PMC8762293]. Additionally, the post-transcriptional interaction between MIR222 and SCD5, as well as the transcriptional regulation of MEF2C by MIR222, have been validated through in vitro and in vivo assays [PMC7584575]. Furthermore, angiotensin-2 has been found to regulate a long nonprotein-coding RNA called lncAng362, which is responsible for the production of two microRNAs involved in vascular smooth muscle cell proliferation: miR221 and MIR222 [PMC7123062]. Finally, miR21, miR124, and MIR222 have been analyzed for their expression in both small extracellular vesicles (sEVs) and medium/large extracellular vesicles (m/lEVs) [PMC10056600]. These findings highlight the diverse functions of MIR222 across various biological processes.

Literature search
396 open access papers mention hsa-mir-222
(2020 sentences)


1155220 reads, 4867 reads per million, 157 experiments

gcu           uaggua  c   au              -     AUC   ucuu 
   gcuggaaggug      cc uca  ggCUCAGUAGCCAG UGUAG   CUg    u
   |||||||||||      || |||  |||||||||||||| |||||   |||    c
   cgaucuucuac      gg agu  cUGGGUCAUCGGUC ACAUC   gac    g
--u           ------  u   cu              U     GAc   uaau 

Annotation confidence High
Do you think this miRNA is real?
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR was validated in zebrafish, and the ends mapped by cloning. Subsequent cloning studies have also verified the expression of miR-222 in human ES cells. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].

Genome context
chrX: 45747015-45747124 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-222
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-222 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-222-5p

Accession MIMAT0004569
Description Homo sapiens hsa-miR-222-5p mature miRNA
Evidence experimental
cloned [4]
Database links
Predicted targets

Mature hsa-miR-222-3p

Accession MIMAT0000279
Description Homo sapiens hsa-miR-222-3p mature miRNA
Evidence experimental
cloned [2-5], Northern [2]
Database links
Predicted targets


  1. PubMed ID: 15183728
    Human embryonic stem cells express a unique set of microRNAs
    "Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS"
    "Dev Biol (2004) 270:488-498

  2. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  3. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  4. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  5. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540