Accession
MI0000342
Symbol
HGNC:
MIR200B
Description
Homo sapiens
hsa-mir-200b precursor miRNA mir-8
Gene
family?
family?
RF00241;
mir-8
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR200B is a microRNA that plays a role in various biological processes, including diabetic retinopathy and epithelial to mesenchymal transition (EMT). In diabetic retinopathy, ANRIL regulates VEGF through interactions with PRC2 components p300, MIR200B, and enhancer of zeste homolog 2 (EZH2) [PMC8427604]. Bisulfite sequencing of the MIR200B promoter region has been performed [PMC4921922]. Epithelial signature genes such as CDH1, GRHL2, and the MIR200B cluster show higher levels of permissive marks (H3K4me3 and H3K27ac) and lower levels of the repressive mark H3K27me3 in cell lines with lower EMT score compared to cell lines with higher EMT score [PMC6656769]. In Hep-12 cells rich in tumor stem cells, MIR200B is downregulated along with other stem miRNAs [PMC7376200]. miPEP200a downregulates vimentin expression independently of miR200a and MIR200B activation [PMC8038077]. The MIR200 family, including MIR200a, MIR200B, MIR200c, MIR141, and MIR429 are targeted by several differentially methylated regions (DMRs) in UCS [PMC5237802]. Exposure to tobacco carcinogens leads to epigenetic silencing of MIR200B along with miR200c and miR205 during epithelial to mesenchymal transition (EMT) in lung epithelial cell cultures [PMC3763404].
Literature search
680 open access papers mention hsa-mir-200b
(4622 sentences)
(4622 sentences)
Sequence
118810
reads,
1272
reads per million, 139 experiments
ccagcucgggcagccguggcCAUCUUACUGGGCAGCAUUGGAuggagucaggucucUAAUACUGCCUGGUAAUGAUGAcggcggagcccugcacg
...((..((((..((((.(.(((((((((((((((.((((((..((......)))))))).))))))))))).)))).).)))).)))).))...
...((..((((..((((.(.(((((((((((((((.((((((..((......)))))))).))))))))))).)))).).)))).)))).))...
Structure
cca uc ag g c - C ug gu gc gggc ccgu g CAUC UUACUGGGCAG AUUGGA ga c || |||| |||| | |||| ||||||||||| |||||| || cg cccg ggcg c GUAG AAUGGUCCGUC UAAUcu cu a gca -u -a g A U A -- gg
Annotation confidence
Not enough data
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].
Genome context
chr1: 1167104-1167198 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-200b
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-200b is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-200b is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-200b is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-200b-5p
| Accession | MIMAT0004571 |
| Description | Homo sapiens hsa-miR-200b-5p mature miRNA |
| Sequence | 21 - CAUCUUACUGGGCAGCAUUGGA - 42 |
| Evidence |
experimental
cloned [4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-200b-3p
| Accession | MIMAT0000318 |
| Description | Homo sapiens hsa-miR-200b-3p mature miRNA |
| Sequence | 57 - UAAUACUGCCUGGUAAUGAUGA - 78 |
| Evidence |
experimental
Northern [1], cloned [2-5] |
| Database links |
|
| Predicted targets |
|
References
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