Accession
MI0000342
Symbol
HGNC:
MIR200B
Description
Homo sapiens
hsa-mir-200b precursor miRNA mir-8
Gene
family?
family?
RF00241;
mir-8
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR200B is a microRNA implicated in various cellular processes, including the regulation of epithelial to mesenchymal transition (EMT) and the maintenance of epithelial characteristics [PMC6656769]. The epigenetic regulation of MIR200B is evident from bisulfite sequencing studies that have characterized its promoter region [PMC4921922]. The expression levels of MIR200B are inversely correlated with EMT scores in various cell lines; cell lines with lower EMT scores exhibit higher levels of MIR200B [PMC6656769]. However, the statement that MIR200B is regulated by ANRIL in the context of diabetic retinopathy is not supported by the provided context [PMC8427604]. Additionally, the claim that low expression levels of MIR200B in cancer stem cells from Hep-12 suggest a role in inhibiting stem cell-associated microRNAs is not substantiated by the context [PMC7376200]. miPEP200a can downregulate vimentin expression without activating miR200a and MIR200B, indicating a mechanism independent of these microRNAs [PMC8038077]. Differential methylation regions (DMRs) have been identified that target the MIR200 family including MIR200B in uterine carcinosarcoma (UCS), indicating that epigenetic modifications can affect its expression [PMC5237802]. Exposure to tobacco carcinogens has been shown to epigenetically silence MIR200B in lung epithelial cells and contribute to EMT phenotypic changes [PMC3763404].
Literature search
680 open access papers mention hsa-mir-200b
(4622 sentences)
(4622 sentences)
Sequence
118810
reads,
1272
reads per million, 139 experiments
ccagcucgggcagccguggcCAUCUUACUGGGCAGCAUUGGAuggagucaggucucUAAUACUGCCUGGUAAUGAUGAcggcggagcccugcacg
...((..((((..((((.(.(((((((((((((((.((((((..((......)))))))).))))))))))).)))).).)))).)))).))...
...((..((((..((((.(.(((((((((((((((.((((((..((......)))))))).))))))))))).)))).).)))).)))).))...
Structure
cca uc ag g c - C ug gu gc gggc ccgu g CAUC UUACUGGGCAG AUUGGA ga c || |||| |||| | |||| ||||||||||| |||||| || cg cccg ggcg c GUAG AAUGGUCCGUC UAAUcu cu a gca -u -a g A U A -- gg
Annotation confidence
Not enough data
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].
Genome context
chr1: 1167104-1167198 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-200b
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-200b is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-200b is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-200b is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-200b-5p
| Accession | MIMAT0004571 |
| Description | Homo sapiens hsa-miR-200b-5p mature miRNA |
| Sequence | 21 - CAUCUUACUGGGCAGCAUUGGA - 42 |
| Evidence |
experimental
cloned [4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-200b-3p
| Accession | MIMAT0000318 |
| Description | Homo sapiens hsa-miR-200b-3p mature miRNA |
| Sequence | 57 - UAAUACUGCCUGGUAAUGAUGA - 78 |
| Evidence |
experimental
Northern [1], cloned [2-5] |
| Database links |
|
| Predicted targets |
|
References
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