Stem-loop hsa-mir-200b

Accession

MI0000342

Symbol

HGNC: MIR200B

Description

Homo sapiens hsa-mir-200b precursor miRNA mir-8

Gene
family

RF00241; mir-8

Literature search

680 open access papers mention hsa-mir-200b
(4622 sentences)

Sequence

118810 reads, 694 reads per million, 139 experiments

ccagcucgggcagccguggcCAUCUUACUGGGCAGCAUUGGAuggagucaggucucUAAUACUGCCUGGUAAUGAUGAcggcggagcccugcacg
...((..((((..((((.(.(((((((((((((((.((((((..((......)))))))).))))))))))).)))).).)))).)))).))...

Structure

cca  uc    ag    g c    -           C      ug  gu 
   gc  gggc  ccgu g CAUC UUACUGGGCAG AUUGGA  ga  c
   ||  ||||  |||| | |||| ||||||||||| ||||||  ||   
   cg  cccg  ggcg c GUAG AAUGGUCCGUC UAAUcu  cu  a
gca  -u    -a    g A    U           A      --  gg 

Annotation confidence Not enough data

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].

Genome context

chr1: 1167104-1167198 [+]

Clustered miRNAs

2 other miRNAs are < 10 kb from hsa-mir-200b

Disease association

hsa-mir-200b is associated with one or more human diseases in the Human microRNA Disease Database

Biological pathways

hsa-mir-200b is involved in one or more biological pathways:

(Source: Reactome)

Biological reactions

hsa-mir-200b is involved in one or more regulation/signalling events:

(Source: Reactome)

Mature hsa-miR-200b-5p

• Accession: MIMAT0004571
• Description: Homo sapiens hsa-miR-200b-5p mature miRNA
• Sequence: 21 - CAUCUUACUGGGCAGCAUUGGA - 42
• Evidence: experimental ; cloned [4]

Mature hsa-miR-200b-3p

• Accession: MIMAT0000318
• Description: Homo sapiens hsa-miR-200b-3p mature miRNA
• Sequence: 57 - UAAUACUGCCUGGUAAUGAUGA - 78
• Evidence: experimental ; Northern [1], cloned [2-5]

References

1. PubMed ID: 12769849
   Computational and experimental identification of C. elegans microRNAs
   "Grad Y, Aach J, Hayes GD, Reinhart BJ, Church GM, Ruvkun G, Kim J"
   "Mol Cell (2003) 11:1253-1263


2. PubMed ID: 14573789
   Reduced accumulation of specific microRNAs in colorectal neoplasia
   "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
   "Mol Cancer Res (2003) 1:882-891


3. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


4. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


5. PubMed ID: 15891114
   Clustering and conservation patterns of human microRNAs
   "Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H"
   "Nucleic Acids Res (2005) 33:2697-2706