miRBase entry: hsa-mir-200b

Stem-loop hsa-mir-200b

Homo sapiens hsa-mir-200b precursor miRNA
Gene family
MIPF0000019; mir-8

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR200B is a microRNA that plays a role in various biological processes, including diabetic retinopathy and epithelial to mesenchymal transition (EMT). In diabetic retinopathy, ANRIL regulates VEGF through interactions with PRC2 components p300, MIR200B, and enhancer of zeste homolog 2 (EZH2) [PMC8427604]. Bisulfite sequencing of the MIR200B promoter region has been performed [PMC4921922]. Epithelial signature genes such as CDH1, GRHL2, and the MIR200B cluster show higher levels of permissive marks (H3K4me3 and H3K27ac) and lower levels of the repressive mark H3K27me3 in cell lines with lower EMT score compared to cell lines with higher EMT score [PMC6656769]. In Hep-12 cells rich in tumor stem cells, MIR200B is downregulated along with other stem miRNAs [PMC7376200]. miPEP200a downregulates vimentin expression independently of miR200a and MIR200B activation [PMC8038077]. The MIR200 family, including MIR200a, MIR200B, MIR200c, MIR141, and MIR429 are targeted by several differentially methylated regions (DMRs) in UCS [PMC5237802]. Exposure to tobacco carcinogens leads to epigenetic silencing of MIR200B along with miR200c and miR205 during epithelial to mesenchymal transition (EMT) in lung epithelial cell cultures [PMC3763404].

Literature search
680 open access papers mention hsa-mir-200b
(4622 sentences)


118810 reads, 1272 reads per million, 139 experiments

cca  uc    ag    g c    -           C      ug  gu 
   gc  gggc  ccgu g CAUC UUACUGGGCAG AUUGGA  ga  c
   ||  ||||  |||| | |||| ||||||||||| ||||||  ||   
   cg  cccg  ggcg c GUAG AAUGGUCCGUC UAAUcu  cu  a
gca  -u    -a    g A    U           A      --  gg 

Annotation confidence Not enough data
Do you think this miRNA is real?
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].

Genome context
chr1: 1167104-1167198 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-200b
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-200b is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-200b is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-200b is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-200b-5p

Accession MIMAT0004571
Description Homo sapiens hsa-miR-200b-5p mature miRNA
Evidence experimental
cloned [4]
Database links
Predicted targets

Mature hsa-miR-200b-3p

Accession MIMAT0000318
Description Homo sapiens hsa-miR-200b-3p mature miRNA
Evidence experimental
Northern [1], cloned [2-5]
Database links
Predicted targets


  1. PubMed ID: 12769849
    Computational and experimental identification of C. elegans microRNAs
    "Grad Y, Aach J, Hayes GD, Reinhart BJ, Church GM, Ruvkun G, Kim J"
    "Mol Cell (2003) 11:1253-1263

  2. PubMed ID: 14573789
    Reduced accumulation of specific microRNAs in colorectal neoplasia
    "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
    "Mol Cancer Res (2003) 1:882-891

  3. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  4. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  5. PubMed ID: 15891114
    Clustering and conservation patterns of human microRNAs
    "Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H"
    "Nucleic Acids Res (2005) 33:2697-2706