Stem-loop dme-mir-276a

Accession

MI0000359

Description

Drosophila melanogaster dme-mir-276a precursor miRNA

Literature search

15 open access papers mention dme-mir-276a
(44 sentences)

Sequence

5108716 reads, 51116 reads per million, 49 experiments

ccugguuuuugccauCAGCGAGGUAUAGAGUUCCUACGuucauuauaaacucgUAGGAACUUCAUACCGUGCUCUuggaagaccaaaaaacaaccaag
..(((((((..(((..((((.(((((.(((((((((((.............))))))))))).))))).))))..)))))))))).............

Structure

-----------cc       ug   uC    A     A           uucau 
             ugguuuu  cca  AGCG GGUAU GAGUUCCUACG     u
             |||||||  |||  |||| ||||| |||||||||||     a
             accagaa  ggu  UCGU CCAUA UUCAAGGAUgc     u
gaaccaacaaaaa       --   UC    G     C           ucaaa 

Annotation confidence Medium

Comments

miR-276 was reported independently in references [1] and [2]. Reference [2] reported a 22 nt excised sequence from the 3' arm of the precursor by cloning. Computational approaches followed by Northern blotting predicted an excised sequence from the 5' arm which is designated miR-276a* here [1].

Genome context

chr3L: 10365228-10365325 [+]

Mature dme-miR-276a-5p

• Accession: MIMAT0000336
• Description: Drosophila melanogaster dme-miR-276a-5p mature miRNA
• Sequence: 16 - CAGCGAGGUAUAGAGUUCCUACG - 38
• Evidence: experimental ; Northern [1], 454 [3-4], Illumina [4]

Mature dme-miR-276a-3p

• Accession: MIMAT0000337
• Description: Drosophila melanogaster dme-miR-276a-3p mature miRNA
• Sequence: 54 - UAGGAACUUCAUACCGUGCUCU - 75
• Evidence: experimental ; Northern [1], cloned [2], 454 [3-4], Illumina [4]

References

1. PubMed ID: 12919683
   The small RNA profile during Drosophila melanogaster development
   "Aravin AA, Lagos-Quintana M, Yalcin A, Zavolan M, Marks D, Snyder B, Gaasterland T, Meyer J, Tuschl T"
   "Dev Cell (2003) 5:337-350


2. PubMed ID: 17989254
   Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs
   "Ruby JG, Stark A, Johnston WK, Kellis M, Bartel DP, Lai EC"
   "Genome Res (2007) 17:1850-1864


3. PubMed ID: 17989255
   Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes
   "Stark A, Kheradpour P, Parts L, Brennecke J, Hodges E, Hannon GJ, Kellis M"
   "Genome Res (2007) 17:1865-1879


4. PubMed ID: 12844358
   Computational identification of Drosophila microRNA genes
   "Lai EC, Tomancak P, Williams RW, Rubin GM"
   "Genome Biol (2003) 4:R42