Accession
MI0000360
Description
Drosophila melanogaster
dme-mir-277 precursor miRNA mir-277
Gene
family?
family?
RF00730;
mir-277
Literature search
43 open access papers mention dme-mir-277
(411 sentences)
(411 sentences)
Sequence
3135063
reads,
24120.0
reads per million, 51 experiments
uugaagguuuugggcugCGUGUCAGGAGUGCAUUUGCACUGaaacuaucugaagcaugUAAAUGCACUAUCUGGUACGACAUuccagaacguacaaucuu
(((.(.((((((((.(((((((((((((((((((((((.((...(.....)...)))))))))))))).))))))))).)).)))))))).).)))....
(((.(.((((((((.(((((((((((((((((((((((.((...(.....)...)))))))))))))).))))))))).)).)))))))).).)))....
Structure
---- a g c - - C aaa u
uug a guuuuggg ug CGUGUCAGG AGUGCAUUUGCA UG c a
||| | |||||||| || ||||||||| |||||||||||| || | u
aac u caagaccu AC GCAUGGUCU UCACGUAAAUgu ac g c
uucu a g U A A - gaa u
Annotation confidence
High
Do you think this miRNA is real?
Comments
miR-277 was reported independently in references [1] and [2]. Computational prediction followed by northern blotting confirmed that the strand containing the predicted miR is predominantly expressed [1]. Reference [2] confirmed the 5' end of the excised miRNA by cloning and reported a length distribution of 21-23 nt with 23 nt the most commonly expressed. Stark et al. [3] have predicted that miR-277 controls the pathway for valine, leucine and isoleucine degradation by downregulating many of its enzymes.
Genome context
chr3R: 10100022-10100121 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from dme-mir-277
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Database links
Mature dme-miR-277-5p
| Accession | MIMAT0020804 |
| Description | Drosophila melanogaster dme-miR-277-5p mature miRNA |
| Sequence | 18 - CGUGUCAGGAGUGCAUUUGCACUG - 41 |
| Evidence | not_experimental |
| Database links |
|
Mature dme-miR-277-3p
| Accession | MIMAT0000338 |
| Description | Drosophila melanogaster dme-miR-277-3p mature miRNA |
| Sequence | 59 - UAAAUGCACUAUCUGGUACGACAU - 82 |
| Evidence |
experimental
Northern [1], cloned [2], 454 [4-5], Illumina [5] |
| Database links |
|
| Predicted targets |
|
References
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