miRBase entry: hsa-mir-125b-1

Stem-loop hsa-mir-125b-1

Homo sapiens hsa-mir-125b-1 precursor miRNA
Gene family
MIPF0000033; mir-10

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR125B1 is a miRNA gene that has been reported as dysregulated in Alzheimer's disease (AD) brains [PMC4861808]. Ten CpG sites, including cg03891346, overlap with miRNA genes that have been previously reported as dysregulated in AD brains, such as MIR34B/C, MIR9-1, MIR34A, MIR146B, MIR124-1, MIR181C/D, MIR451, and MIR9-3 [PMC4861808]. Specifically, cg03891346 annotated to MIR125B1 has been associated with the expression level of miR-100-5p [PMC7056871]. These findings suggest a potential role of dysregulated miRNA genes in the pathogenesis of AD [PMC4861808]. Further research is needed to understand the specific mechanisms by which these dysregulated miRNAs contribute to the development and progression of AD [PMC4861808].

Literature search
685 open access papers mention hsa-mir-125b-1
(4187 sentences)


802721 reads, 5007 reads per million, 157 experiments

u    uc   u    C       C           Au     c 
 gcgc  cuc cagU CCUGAGA CCUAACUUGUG  guuua c
 ||||  ||| |||| ||||||| |||||||||||  ||||| g
 cgug  gag gUCG GGGUUCU GGAUUGGGCAc  uaaau u
u    cu   c    A       C           -c     u 

Annotation confidence High
Do you think this miRNA is real?
This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1]. Its expression was later verified in human BC-1 cells [2].

Genome context
chr11: 122099757-122099844 [-]

Disease association
hsa-mir-125b-1 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-125b-5p

Accession MIMAT0000423
Description Homo sapiens hsa-miR-125b-5p mature miRNA
Evidence experimental
cloned [2,4-6], Illumina [7]
Database links
Predicted targets

Mature hsa-miR-125b-1-3p

Accession MIMAT0004592
Description Homo sapiens hsa-miR-125b-1-3p mature miRNA
Evidence experimental
cloned [5]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PubMed ID: 20158877
    Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha
    Koh W, Sheng CT, Tan B, Lee QY, Kuznetsov V, Kiang LS, Tanavde V
    BMC Genomics (2010) 11:S6

  4. PubMed ID: 15978578
    Identification of human fetal liver miRNAs by a novel method
    "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
    "FEBS Lett (2005) 579:3849-3854

  5. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739

  6. PubMed ID: 15800047
    Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells
    "Cai X, Lu S, Zhang Z, Gonzalez CM, Damania B, Cullen BR"
    "Proc Natl Acad Sci U S A (2005) 102:5570-5575

  7. PubMed ID: 15722555
    Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation
    "Lee YS, Kim HK, Chung S, Kim KS, Dutta A"
    "J Biol Chem (2005) 280:16635-16641