Accession
MI0000449
Symbol
HGNC:
MIR132
Description
Homo sapiens
hsa-mir-132 precursor miRNA mir-132
Gene
family?
family?
RF00662;
mir-132
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
hsa-mir-132, a microRNA, has been found to be consistently downregulated in Alzheimer's disease (AD), affecting both brain and blood samples, including neurally-derived extracellular vesicles [PMC10064073]. This downregulation also extends to its interaction with the long non-coding RNA SNHG5, which in turn regulates the GATA3 gene via hsa-mir-132 and hsa-miR-92 [PMC8123229]. However, while hsa-mir-132 is among a group of microRNAs predicted to target CDKN1A, its role in this regulatory mechanism has not been confirmed through validation studies [PMC6434248].
Literature search
285 open access papers mention hsa-mir-132
(1581 sentences)
(1581 sentences)
Sequence
54874
reads,
1698
reads per million, 128 experiments
ccgcccccgcgucuccagggcaACCGUGGCUUUCGAUUGUUACUgugggaacuggaggUAACAGUCUACAGCCAUGGUCGccccgcagcacgcccacgcgc
.(((....((((((.(.((((.(((((((((...((((((((((..(....)....))))))))))...))))))))).)))).).)).))))....))).
.(((....((((((.(.((((.(((((((((...((((((((((..(....)....))))))))))...))))))))).)))).).)).))))....))).
Structure
c cccc - c a a UUC --gu g cgc gcgu cu c gggc ACCGUGGCU GAUUGUUACU g g ||| |||| || | |||| ||||||||| |||||||||| | gcg cgca ga g cccG UGGUACCGA CUGACAAUgg c a c cacc c c c C CAU aggu a
Annotation confidence
High
Do you think this miRNA is real?
Comments
This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1], later verified in human [2].
Genome context
chr17: 2049908-2050008 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-132
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-132 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-132 is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-132 is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-132-5p
| Accession | MIMAT0004594 |
| Description | Homo sapiens hsa-miR-132-5p mature miRNA |
| Sequence | 23 - ACCGUGGCUUUCGAUUGUUACU - 44 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-132-3p
| Accession | MIMAT0000426 |
| Description | Homo sapiens hsa-miR-132-3p mature miRNA |
| Sequence | 59 - UAACAGUCUACAGCCAUGGUCG - 80 |
| Evidence |
experimental
cloned [2-3] |
| Database links |
|
| Predicted targets |
|
References
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