hsa-mir-132, a microRNA, has been found to be consistently downregulated in Alzheimer's disease (AD), affecting both brain and blood samples, including neurally-derived extracellular vesicles [PMC10064073]. This downregulation also extends to its interaction with the long non-coding RNA SNHG5, which in turn regulates the GATA3 gene via hsa-mir-132 and hsa-miR-92 [PMC8123229]. However, while hsa-mir-132 is among a group of microRNAs predicted to target CDKN1A, its role in this regulatory mechanism has not been confirmed through validation studies [PMC6434248].
c cccc - c a a UUC --gu g cgc gcgu cu c gggc ACCGUGGCU GAUUGUUACU g g ||| |||| || | |||| ||||||||| |||||||||| | gcg cgca ga g cccG UGGUACCGA CUGACAAUgg c a c cacc c c c C CAU aggu a
Name | Accession | Chromosome | Start | End | Strand | Confidence |
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Disease | Description | Category | PubMed ID |
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Accession | MIMAT0004594 |
Description | Homo sapiens hsa-miR-132-5p mature miRNA |
Sequence | 23 - ACCGUGGCUUUCGAUUGUUACU - 44 |
Evidence |
experimental
cloned [2] |
Database links |
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Predicted targets |
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Accession | MIMAT0000426 |
Description | Homo sapiens hsa-miR-132-3p mature miRNA |
Sequence | 59 - UAACAGUCUACAGCCAUGGUCG - 80 |
Evidence |
experimental
cloned [2-3] |
Database links |
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Predicted targets |
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