miRBase entry: hsa-mir-141

Stem-loop hsa-mir-141

Homo sapiens hsa-mir-141 precursor miRNA
Gene family
MIPF0000019; mir-8

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR141 is a microRNA that functions as a tumor suppressor by repressing ZEB1, an inducer of epithelial-mesenchymal transition (EMT) [PMC4673276]. Two cell lines, 10A-iK8 and 231-K8ikd, were infected with viruses derived from pLenti 4.1 MIR141 and selected with puromycin to generate 10A-iK8-MIR141 and 231-K8ikd-MIR141 cell lines [PMC4673276]. The overexpression of MIR141 inhibited tumor growth in a manner comparable to the knockdown of KLF8 (U + MIR141) [PMC4673276]. MIR141 was found to directly regulate PD-L1, which is involved in the immune escape of stomach cancer cells [PMC7468375]. The expression of mature hsa-miR-141-3p was significantly reduced upon targeting MIR141 compared to the control [PMC8021117]. Abnormal expression of MIR141 was observed in placental tissues from preeclampsia (PE) patients, and elevated levels of MIR141 were transferred from trophoblasts to immune cells through extracellular vesicles (EVs) [PMC9104507]. The U47924.27 locus containing MIR200C and MIR141 was found to be hypo-methylated at its promoter and overexpressed in gastric cancer [PMC5041931]. In a study on Kallmann syndrome patients, genes from the mir-200 family including MIR141 were screened due to their known role in olfactory system development and GnRH neuron development [PMC6479198].

[PMC4673276]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673276/
[PMC7468375]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468375/
[PMC8021117]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021117/
[PMC9104507]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104507/
[PMC5041931]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041931/
[PMC6479198]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479198/

Literature search
359 open access papers mention hsa-mir-141
(1909 sentences)


93091 reads, 931 reads per million, 140 experiments

c    g    u   -u       --    U        -   ugg  ua 
 ggcc gccc ggg  cCAUCUU  CCAG ACAGUGUU GGA   uc  a
 |||| |||| |||  |||||||  |||| |||||||| |||   ||  u
 uugg uggg ccc  GGUAGAA  GGUC UGUCACAA ccu   ag  u
c    g    -   uc       AU    -        U   cga  ug 

Annotation confidence High
Do you think this miRNA is real?
This miRNA sequence was predicted based on homology to a verified miRNA from mouse [1]. Michael et al. subsequently verified expression of miR-141 in human [2].

Genome context
chr12: 6964097-6964191 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-141
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-141 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-141-5p

Accession MIMAT0004598
Description Homo sapiens hsa-miR-141-5p mature miRNA
Evidence experimental
cloned [3]
Database links
Predicted targets

Mature hsa-miR-141-3p

Accession MIMAT0000432
Description Homo sapiens hsa-miR-141-3p mature miRNA
Evidence experimental
cloned [2-4]
Database links
Predicted targets


  1. PubMed ID: 14573789
    Reduced accumulation of specific microRNAs in colorectal neoplasia
    "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
    "Mol Cancer Res (2003) 1:882-891

  2. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  3. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  4. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739