Accession
MI0000457
Symbol
HGNC:
MIR141
Description
Homo sapiens
hsa-mir-141 precursor miRNA mir-8
Gene
family?
family?
RF00241;
mir-8
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR141 is a microRNA that functions as a tumor suppressor by repressing ZEB1, an inducer of epithelial-mesenchymal transition (EMT) [PMC4673276]. Two cell lines, 10A-iK8 and 231-K8ikd, were infected with viruses derived from pLenti 4.1 MIR141 and selected with puromycin to generate 10A-iK8-MIR141 and 231-K8ikd-MIR141 cell lines [PMC4673276]. The overexpression of MIR141 inhibited tumor growth in a manner comparable to the knockdown of KLF8 (U + MIR141) [PMC4673276]. MIR141 was found to directly regulate PD-L1, which is involved in the immune escape of stomach cancer cells [PMC7468375]. The expression of mature hsa-miR-141-3p was significantly reduced upon targeting MIR141 compared to the control [PMC8021117]. Abnormal expression of MIR141 was observed in placental tissues from preeclampsia (PE) patients, and elevated levels of MIR141 were transferred from trophoblasts to immune cells through extracellular vesicles (EVs) [PMC9104507]. The U47924.27 locus containing MIR200C and MIR141 was found to be hypo-methylated at its promoter and overexpressed in gastric cancer [PMC5041931]. In a study on Kallmann syndrome patients, genes from the mir-200 family including MIR141 were screened due to their known role in olfactory system development and GnRH neuron development [PMC6479198]. References: [PMC4673276]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673276/ [PMC7468375]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468375/ [PMC8021117]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021117/ [PMC9104507]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104507/ [PMC5041931]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041931/ [PMC6479198]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479198/
Literature search
359 open access papers mention hsa-mir-141
(1909 sentences)
(1909 sentences)
Sequence
93091
reads,
931
reads per million, 140 experiments
cggccggcccugggucCAUCUUCCAGUACAGUGUUGGAuggucuaauugugaagcuccUAACACUGUCUGGUAAAGAUGGcucccggguggguuc
.((((.((((.(((.(((((((((((.(((((((((((...((.......))...))).))))))))))))..)))))))..))))))).)))).
.((((.((((.(((.(((((((((((.(((((((((((...((.......))...))).))))))))))))..)))))))..))))))).)))).
Structure
c g u -u -- U - ugg ua ggcc gccc ggg cCAUCUU CCAG ACAGUGUU GGA uc a |||| |||| ||| ||||||| |||| |||||||| ||| || u uugg uggg ccc GGUAGAA GGUC UGUCACAA ccu ag u c g - uc AU - U cga ug
Annotation confidence
High
Do you think this miRNA is real?
Comments
This miRNA sequence was predicted based on homology to a verified miRNA from mouse [1]. Michael et al. subsequently verified expression of miR-141 in human [2].
Genome context
chr12: 6964097-6964191 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-141
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-141 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-141-5p
| Accession | MIMAT0004598 |
| Description | Homo sapiens hsa-miR-141-5p mature miRNA |
| Sequence | 17 - CAUCUUCCAGUACAGUGUUGGA - 38 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-141-3p
| Accession | MIMAT0000432 |
| Description | Homo sapiens hsa-miR-141-3p mature miRNA |
| Sequence | 59 - UAACACUGUCUGGUAAAGAUGG - 80 |
| Evidence |
experimental
cloned [2-4] |
| Database links |
|
| Predicted targets |
|
References
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